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Compartment- and model-independent linear plateau principle of drugs during a constant-rate absorption or intravenous infusion

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Abstract

A simple general equation is derived to show the linear plateau principle under various conditions during or after a constant or changing rate of absorption or intravenous infusion. The time required to cause a certain fraction (ft) of the total shift or change between the two steady-state plasma concentrations is equal to the time required for the cumulative (from time zero) plasma area, AUC0→t, to reach the same fraction of AUC0→∞ assumed to be obtained after an instantaneousintravenous dosing. The role of the terminal biological half-life and the importance of the earlydistribution phase and its exponential half-life or lives in the plateau principle are discussed.Clinical implications and applications to multiple dosage regimens are also discussed.

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Chiou, W.L. Compartment- and model-independent linear plateau principle of drugs during a constant-rate absorption or intravenous infusion. Journal of Pharmacokinetics and Biopharmaceutics 8, 311–318 (1980). https://doi.org/10.1007/BF01059648

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Key words

  • linear pharmacokinetics
  • plateau principle
  • drug accumulation
  • intravenous infusion
  • zero-order absorption
  • plasma area under the curve