Simultaneous pharmacokinetic and pharmacodynamic modeling
- 312 Downloads
The compartmental model approach previously proposed by Sheiner et al.for the simultaneous characterization of the pharmacokinetics and pharmacodynamics of a drug substance has been rigorously tested and extended in the present report. Pharmacokinetic and pharmacodynamic equations were derived for several commonly used models, as well as alternate models that relate effect to drug concentrations in a peripheral compartment. The versatility and flexibility of these models were tested using simulation and curve-fitting procedures. The utility as well as the limitations of this modeling procedure are discussed.
Key wordspharmacokinetic model pharmacodynamic model compartmental model pharmacologic effect simulation curve-fit
Unable to display preview. Download preview PDF.
- 5.Y. Masuda, Y. Utsui, Y. Shiraishi, T. Karasawa, K. Yoshida, and M. Shimizu. Pharmacokinetics and pharmacokinetic tolerance of a new anticonvulsant agent (3-sulfamoyl-methyl-1,2-benzisoxazole) compared to phenobarbital, diphenylhydantoin, and carbarnazepine in rats.Arch. Int. Pharmacodyn. 240:79–89 (1979).PubMedGoogle Scholar