Neurophysiology

, Volume 26, Issue 5, pp 287–293 | Cite as

Activity of sensorimotor cortex neurons during a dopaminergic transmission block in cats performing conditional reflex

  • V. M. Storozhuk
  • A. V. Sanzharovskii
  • L. I. Trofimchuk
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Abstract

Activity of sensorimotor cortex neurons was recorded in chronic experements on cats trained to perform instrumental conditional reflex; records were made before, during, and after isolated iontophoretic applications of haloperidol or glutamate, or their combined application. Haloperidol was shown either to facilitate or to inhibit the background and evoked (related to acoustic stimulation and motor response) spike activity of cortical neurons. Aftereffects of haloperidol were observed too; they were still expressed 10–15 min after the cessation of the iontophoresis. Combined haloperidol and glutamate application was followed by a sharp suppression of the evoked responses potentiated earlier by glutamate. An adenylatecyclase system is supposed to mediate the facilitation evoked by glutamate application. Some modulators, including dopamine, probably activate adenylatecyclase and in this way ensure facilitation of the glutamate-induced responses.

Keywords

Dopamine Glutamate Haloperidol Cortical Neuron Motor Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • V. M. Storozhuk
    • 1
  • A. V. Sanzharovskii
    • 1
  • L. I. Trofimchuk
    • 1
  1. 1.Bogomolets Institute of PhysiologyNational Academy of Sciences of UkraineKievUkraine

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