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Quantitative gas chromatographic determination of perfluorooctanoic acid as the benzyl ester in plasma and urine

  • Markku Ylinen
  • Hannu Hanhijärvi
  • Pekka Peura
  • Osmo Rämö
Article

Abstract

A method is presented for the quantitative determination of perfluorooctanoic acid in plasma and urine. The acid was esterified by an extractive alkylation method using tetrabutylammonium ion as the counter ion and benzyl bromide as the alkylating agent. Quantitation was made by gas chromatography. Typical values for precision obtained in the determination of 5 μg/ml of perfluorooctanoic acid in plasma and urine were 3.3% (S.D. N=6) and 3.0% (S.D. N=6), respectively. The limit of detection was 1 ng (2.4 pmol).

Keywords

Ester Waste Water Bromide Water Pollution Benzyl 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1985

Authors and Affiliations

  • Markku Ylinen
    • 1
  • Hannu Hanhijärvi
    • 1
    • 2
  • Pekka Peura
    • 1
  • Osmo Rämö
    • 1
  1. 1.Department of Pharmaceutical ChemistryUniversity of KuopioKuopioFinland
  2. 2.Department of Environmental Hygiene and ToxicologyNational Public Health InstituteKuopioFinland

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