Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Combined effect of metals on biogenic amines and their distribution in the brain of mice

  • 30 Accesses

  • 12 Citations


The toxic effects of manganese in combination with iron or copper on the brain tissue of mice were investigated. The combined administration of manganese and iron decreased the accumulation of manganese in the brain compared to manganese treatment alone. This indicated that excess iron may influence the absorption of manganese. Combined exposure to manganese and copper resulted in marked accumulation of copper in the brain. This is of great concern, since excess copper in brain produces incoordination in body movements. Thus, the combined exposure of these two metals, even in permissible limits, may produce serious brain dysfunctions. The combined administration of manganese with iron or copper has also significantly altered the levels of brain tryptophan and 5-hydroxytryptamine.

This is a preview of subscription content, log in to check access.


  1. Chandra, Satya V., and S. K. Tandon: Enhanced manganese toxicity in iron-deficient rats. Environ. Physiol. Biochem.3, 230 (1973).

  2. Denckla, W. D., and H. K. Dewey: The determination of tryptophan in plasma, liver and urine. J. Lab. Clin. Med.69, 160 (1967).

  3. Donaldson, J., T. St. Pierre, J. L. Minnich, and A. Barbeau: Determination of Na+, K+, Mg2+, Ca+2, Zn2+ and Mn2+ in rat brain regions. Canad. J. Biochem.51, 87 (1973).

  4. Donaldson, J., T. Cloutier, J. L. Minnich, and A. Barbeau: Trace metals and biogenic amines in rat brain. In F. H. McDowell and A. Barbeau (ed.): Advances in Neurology. Vol. 5, pp. 245. New York: Raven Press (1974).

  5. Hrdina, P. D., D. A. V. Peters, and R. L. Singhai: Effects of chronic exposure to cadmium, lead, and mercury on brain biogenic amines in the rat. Res. Commun. Chem, Path. & Pharmacol.15, 483 (1976).

  6. Magos, L., and M. Webb: The interaction between cadmium, mercury, and zinc administered subcutaneously in a single injection. Arch. Toxicol.36, 53 (1976).

  7. National Academy of Sciences: Medical and biological effects of environmental pollutants-Copper. Washington, D.C. U.S.A. (1977).

  8. Mena, I., K. Horiuchi, K. Burke, and G. C. Cotzias: Chronic manganese poisoning, individual susceptibility and absorption of iron. Neurology19, 1000 (1969).

  9. Purves, D: Trace element contamination of the environment Amsterdam: Elsevier (1977).

  10. Sadavongvivad, C. Pharmacological significance of biogenic amines in the lungs. Brit. J. Pharmacol.38, 353 (1970).

  11. Shukla, G. S., S. Singh, and S. V. Chandra: The interaction between manganese and ethanol in rats. Acta. Pharmacol et toxicol.43, 354 (1978).

  12. Singh, S., G. S. Shukla, and S. V. Chandra: Influence of ethanol on manganese neurotoxicity in rats. Arch. Toxicol. In press (1978).

  13. Tolonen, M. Industrial toxicology of manganese. Wk. Environ, Hlth.9, 53 (1972).

  14. Waalkes, T. P. and S. Udenfriend: A fluorometric method for the estimation of tyrosine in plasma and tissues. J. Lab. Clin. Med.50, 733 (1957).

  15. Webb, M: Protection by zinc against cadmium toxicity. Biochem. Pharmacol.21, 2767 (1972).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Chandra, S.V., Shukla, G.S., Srivastava, R.S. et al. Combined effect of metals on biogenic amines and their distribution in the brain of mice. Arch. Environ. Contam. Toxicol. 9, 79–85 (1980). https://doi.org/10.1007/BF01055501

Download citation


  • Iron
  • Copper
  • Waste Water
  • Manganese
  • Water Pollution