, Volume 27, Issue 1, pp 19–23 | Cite as

Effects of dexamethasone on the electrical activity of spinal neurons in rats with the transected sciatic nerve

  • V. A. Chavushyan
  • L. A. Matinyan
  • A. S. Andreasyan
  • T. K. Kipriyan


Effects of the glucocorticoid hormone dexamethasone on the reflex discharges in the lumbar ventral roots and background activity (BA) of single neurons in the dorsal laminae of spinal grey were studied in rats after transection of the sciatic nerve. Administration of the hormone during early post-traumatic period (up to seven days) evoked no significant changes in the amplitude of increased (due to the postdenervation hyperreflexia) monosynaptic discharges on the side of nerve transection. At the same time, the monosynaptic discharges grew by 150–170% on the intact side. During later post-transection periods (up to 35 days), when ventral root reflex discharges were suppressed, dexamethasone facilitated reflex transmission via the polysynaptic segmental pathways on both the operated and intact sides. Nonetheless, the monosynaptic component of reflex discharges on the injured side did not recover. Dexamethasone treatment resulted in an increase in the number of BA-generating interneurons within the superficial dorsal horn laminae, and in a decrease in the proportion of units generating bursting activity (possibly of pathological nature).


Dexamethasone Sciatic Nerve Dorsal Horn Spinal Neuron Ventral Root 
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  1. 1.
    M. G. Leedy, M. S. Beattie, and J. C. Bresnahan, “Testosterone-induced plasticity of synaptic inputs to adult mammalian motoneurons,”Brain Res.,424, No. 2, 386–390 (1987).Google Scholar
  2. 2.
    H. A. Yu Wan, “Survival of motoneurons following axotomy is enhanced by lactation or by progesterone treatment,”Brain Res.,491, No. 2, 379–382 (1989).Google Scholar
  3. 3.
    T. K. Kipriyan, “Effects of desoxycorticosterone on background activity of spinal neurons of rat,”Dokl. Akad. Nauk of Armenian SSR,57, 53–57 (1973).Google Scholar
  4. 4.
    T. K. Kipriyan, “Changes in electrical activity of spinal cord neurons of the cat evoked by hydrocortisone,”Neirofiziologiya,6, No. 3, 260–265 (1974).Google Scholar
  5. 5.
    P. M. Mantulo, E. A. Makii, and I. Ya. Serdyuchenko, “Segmental reflex reactions of the rat spinal cord after transection of the sciatic nerve and injection of thyroxine,”Fiziol. Zh.,25, No. 5, 492–496 (1979).Google Scholar
  6. 6.
    T. K. Kipriyan and V. A. Chavushyan, “Changes in the electrical activity of spinal cord neurons of adrenalectomized rats under the effect of corticosteroid hormones,”Neirofiziologiya,21, No. 2, 233–238 (1989).Google Scholar
  7. 7.
    I. Ya. Serdyuchenko, G. E. Koropova, and M. B. Shcherbinina, “Segmental reflex peculiarities after damage of the sciatic nerve in thyroxinized animals,”Neirofiziologiya,24, No. 6, 653–659 (1992).Google Scholar
  8. 8.
    S. H. Chung, J. Y. Lettwin, and S. A. Raymonds, “The GLOGE: a simple device for interspike interval analysis,”J. Physiol.,239, No. 2, 63–66 (1974).Google Scholar
  9. 9.
    E. A. Makii and I. Ya. Serdyuchenko, “Evoked activity of the spinal cord neurons in early periods after transection of the sciatic nerve,”Neirofiziologiya,24, No. 3, 306–314 (1992).Google Scholar
  10. 10.
    P. G. Kostyuk and O. A. Krishtal',Mechanisms Underlying the Electrical Excitability of Nerve Cell [in Russian], Nauka, Moscow (1981).Google Scholar
  11. 11.
    Ch. G. Van Bohemen, P. H. Eliard, and G. G. Roussean, “Control by calcium ions of steroid binding to the glucocorticoid receptor,”Mol. Physiol.,4, No. 1/2, 95–110 (1983).Google Scholar
  12. 12.
    R. D. Andrew R. D, “Endogenous bursting by supraoptic neuroendocrine cells is calcium-dependent,”J. Physiol.,384, Mar., 451–465 (1987).Google Scholar
  13. 13.
    T. K. Kipriyan, “Neurotropic effects of corticosteroid hormones,”Armenian Biol. Zh.,40, No. 2, 123–128 (1987).Google Scholar
  14. 14.
    B. Ozegovic and S. Milkovic, “Role of corticosteroids in the control of lipid and protein content of the rat kidney plasma and brushborder membranes,”Period. Biologorum.,85, No. 4, 355–360 (1983).Google Scholar
  15. 15.
    G. Telegdy, “Hormone-induced alteration in brain transmitter metabolism and brain function,”Endocrinol. Exp.,16, No. 3/4, 217–227 (1982).Google Scholar
  16. 16.
    G. E. Duncan and W. E. Stumpf, “Target neurons for [3H] corticosterone in the rat spinal cord,”Brain Res.,307, No. 1/2, 321–326 (1984).Google Scholar

Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • V. A. Chavushyan
    • 1
  • L. A. Matinyan
    • 1
  • A. S. Andreasyan
    • 2
  • T. K. Kipriyan
    • 2
  1. 1.Orbeli Institute of PhysiologyNational Academy of Sciences of ArmeniaYerevanArmenia
  2. 2.Institute of Applied Problems of PhysicsNational Academy of Sciences of ArmeniaYerevanArmenia

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