Neurophysiology

, Volume 18, Issue 2, pp 109–114 | Cite as

Restoration of evoked responses in the rat dorsomedial thalamic nucleus after amygdaloid lesion

  • B. M. Sidorov
Article
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Abstract

The changing pattern of focal potentials in the thalamic dorsomedial nucleus, produced by stimulating the periamygdaloid cortex between 2 and 90 days after unilateral destruction of the basolateral amygdaloid nuclei, was investigated during semichronic experiments on anesthetized rats. A comparison was made between the parameters and spatio-temporal characteristics of potentials, as revealed at different stages of functional reorganization of thalamo-limbic interaction. The biggest increase in latency to peak of the principal positive-negative component is seen during the first two months after amygdaloid lesion. The original pattern and numerical features of focal potentials are restored in 2.5 months. The potentials formed during the course of the compensatory process differed from those of animals with an intact CNS, however, the amplitude of their test response to paired stimuli being incompletely restored, especially at interstimulus intervals of 40–150 msec. Findings indicate the high functional plasticity of the neural fibers mediating afferents at the level of the above thalamic association nucleus.

Keywords

Interstimulus Interval Thalamic Nucleus Paired Stimulus Compensatory Process Amygdaloid Nucleus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Plenum Publishing Corporation 1986

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  • B. M. Sidorov

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