Journal of Neuro-Oncology

, Volume 15, Issue 3, pp 269–273 | Cite as

Methotrexate induced brain necrosis and severe leukoencephalopathy due to disconnection of an Ommaya device

  • Ron de Waal
  • Paul R. Algra
  • Jan J. Heimans
  • John G. Wolbers
  • Philip Scheltens
Clinical Study


A 63-year old woman with breast carcinoma developed leucoencephalopathy and local brain necrosis after intraparenchymal infusion of methotrexate. This iatrogenic condition was caused by drain disconnection of the Ommaya device (bore hole type). The diagnosis of this rare complication of an Ommaya device was based on multiplanar MR-imaging. The case is discussed with regard to the complications of intraventricular chemotherapy by means of an Ommaya reservoir.

Key words

brain necrosis leptomeningeal carcinomatosis leucoencephalopathy Magnetic Resonance methotrexate Ommaya device 


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Copyright information

© Kluwer Academic Publishers 1993

Authors and Affiliations

  • Ron de Waal
    • 1
  • Paul R. Algra
    • 2
  • Jan J. Heimans
    • 1
  • John G. Wolbers
    • 3
  • Philip Scheltens
    • 1
  1. 1.Department of NeurologyFree University HospitalMB AmsterdamThe Netherlands
  2. 2.Department of RadiologyFree University HospitalMB AmsterdamThe Netherlands
  3. 3.Department of NeurosurgeryFree University HospitalMB AmsterdamThe Netherlands

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