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Glycoconjugate Journal

, Volume 5, Issue 4, pp 499–512 | Cite as

Red cell H-deficient, salivary ABH secretor phenotype of Reunion island. Genetic control of the expression of H antigen in the skin

  • Rosella Mollicone
  • Annem Dalix
  • Anita Jacobsson
  • Bo E Samuelsson
  • Gilbert Gerard
  • Karine Crainic
  • Thierry Callard
  • Jacques Le Pendu
  • Rafael Oriol
Article

Abstract

Based on the genetic model proposing thatH andSe are two structural genes, we predicted that the red cell H-deficient, salivary ABH secretor phenotype should be found on Reunion island, where a large series of H-deficient non-secretor families have been previously described. Two such Reunion individuals are now reported. POU [Ah, Le(a−b+), secretor of A, H, Lea and Leb in saliva] and SOU [Oh, Le(a−b+), secretor of H, Lea and Leb in saliva]. Both are devoid of H α-2-fucosyltransferase activity in serum. In addition, the preparation of total non-acid glycosphingolipids from plasma and red cells of POU revealed the type 1ALeb heptaglycosylceramide and small amounts of the monofucosylated type 1 A hexaglycosylceramide. Both glycolipids possess an H structure probably synthesised by the product of theSe gene. No other blood group A glycolipids, with types 2, 3 or 4 chains, normally present in the presence of the product of theH gene, were found on red cells or plasma of POU.

TheH,Se andLe genetic control of the expression of ABH and related antigens in different tissue structures of the skin is described in 54 H-normal individuals of known ABO, secretor and Lewis phenotypes; in one red cell H-deficient salivary secretor (SOU); and in one H-deficient non-secretor (FRA). Sweat glands express ABH under the control of theSe gene. Sweat ducts express ABH under the control of bothH andSe genes and Lewis antigens under the control ofLe and bothH andSe genes. Epidermis, vascular endothelium and red cells express ABH under the control of theH gene. The products ofH andSe genes are usually expressed in different cells. However, the results illustrate that in some structures, like the epithelial cells of sweat ducts, both the products ofH andSe genes can contribute to the synthesis of the same Leb structure.

Key words

ABH, H-deficient secretor skin genetic control of H expression 

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Copyright information

© Glycoconjugate Journal 1988

Authors and Affiliations

  • Rosella Mollicone
    • 1
  • Annem Dalix
    • 1
  • Anita Jacobsson
    • 2
  • Bo E Samuelsson
    • 2
  • Gilbert Gerard
    • 3
  • Karine Crainic
    • 4
  • Thierry Callard
    • 1
  • Jacques Le Pendu
    • 1
  • Rafael Oriol
    • 1
  1. 1.Institut d'Immunobiologie, CNRS ER-281Broussais HospitalParis Cedex 14France
  2. 2.Department of Medical BiochemistryUniversity of GöteborgSweden
  3. 3.Centre de transfusion sanguineBellepierre HospitalSaint Denis, Reunion Island
  4. 4.Institut de Médecine LégaleParisFrance

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