A prevalence study of autism in tuberous sclerosis
- 172 Downloads
An estimate of the prevalence of autism in tuberous sclerosis (TSC) was made by interviewing the parents of 21 children between ages 3 and 11 ascertained during a previous population study of the condition in the West of Scotland. Five of the children (24%) were rated autistic and a further four (19%), all of whom were girls, has socially impaired behavior categorized as pervasive developmental disorder, without fulfilling all the DSM-III-R criteria for autism. One further boy had disruptive attention-seeking behavior that had excluded him from his, normal school. The estimated prevalence from this study of autism in TSC is 1 in 4 children in general, and 1 in 2 of those with mental retardation. Tuberous sclerosis could be a significant cause of autism and pervasive developmental disorders, particularly in girls.
KeywordsMental Retardation Prevalence Study Developmental Disorder Tuberous Sclerosis Pervasive Developmental Disorder
Unable to display preview. Download preview PDF.
- Bruce, A. (1967). Infantile autism.New Zeland Medical Journal, 66, 895–897.Google Scholar
- Coleman, M., & Gillberg, C. (1985).The biology of the autistic Syndromes. New York: Praeger.Google Scholar
- Connor, J. M. (1990). Epidemiology and genetic approaches in tuberous sclerosis. In Y. Ishibasi and Y. Hori (Eds.),Tuberous sclerosis and neurofibromatosis: Epidemiology, pathophysiology, biology and management (pp. 55–62), Amsterdam: Elsevier.Google Scholar
- Critchley, M., & Earl, C. J. C. (1932). Tuberous sclerosis and allied conditions.Brain, 55, 311–346.Google Scholar
- Gomez, M. R. (1988).Tuberous sclerosis (pp. 9–19). New York: Raven.Google Scholar
- Houser, O. W., & Nixon, J. R. (1988). Central nervous system imaging. In M. R. Gomez (Ed.),Tuberous sclerosis (pp. 51–62). New York: Raven.Google Scholar
- Kanner L. (1943). Autistic disturbance of affective contact.Nervous Child, 2, 217–250.Google Scholar
- Maki, Y., Enomoto, T., Maruyama, H., & Maekawa, K. (1979). Computed tomography in tuberous sclerosis.Brain & Development, 1, 38–48.Google Scholar
- Quine, L. (1991). Sleep problems with mental handicap.Journal of Mental Deficiency Research, 35, 349–354.Google Scholar
- Rutter, M., & Hersov, L. (1977).Child Psychiatry: Modem approaches. Oxford. Blackwell.Google Scholar
- Steffanson, K., Wollmann., R. L., & Huttenlocher, P. R. (1988). Lineages of cells in the central nervous system. In M. R. Gomez (Ed.),Tuberous sclerosis (pp. 75–87). New York: Raven.Google Scholar