Nitrilase-catalyzed production of<Emphasis Type="Underline">p</Emphasis>-aminobenzoic acid from<Emphasis Type="Underline">p</Emphasis>-aminobenzonitrile with<Emphasis Type="Underline">Rhodococcus</Emphasis><Emphasis Type="Underline">rhodochrous</Emphasis> J1

Michihiko Kobayashi; Toru Nagasawa; Noriyuki Yanaka; Hideaki Yamada

doi:10.1007/BF01026781

Biotechnology Letters

January 1989, Volume 11, Issue 1, pp 27–30 | Cite as

Nitrilase-catalyzed production ofp-aminobenzoic acid fromp-aminobenzonitrile withRhodococcusrhodochrous J1

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Authors and affiliations

Michihiko Kobayashi
Toru Nagasawa
Noriyuki Yanaka
Hideaki Yamada

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Summary

The reaction conditions for the enzymatic production ofp-aminobenzoic acid were optimized, using a nitrilase in cells ofRhodococcusrhodochrous J1. The highest accumulation, 110 gp-aminobenzoic acid/liter of reaction mixture, was attained fromp-aminobenzonitrile, with a conversion yield of 100%.

Keywords

Organic Chemistry Bioorganic Chemistry Enzymatic Production High Accumulation Conversion Yield

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References

Kobayashi, M., Nagasawa, T., and Yamada, H. (1988)Appl. Microbiol. Biotechnol.,29, 231–233.Google Scholar
Mathew, C. D., Nagasawa, T., Kobayashi, M. and Yamada, H. (1988)Appl. Environ. Microbiol.,54, 1030–1032.Google Scholar
Nagasawa, T., Kobayashi, M., and Yamada, H. (1988a)Arch. Microbiol.,150, 89–94.Google Scholar
Nagasawa, T., Mathew, C. D., Mauger, J., and Yamada, H. (1988b)Appl. Environ. Microbiol. 54, 1766–1769.Google Scholar

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Authors and Affiliations

Michihiko Kobayashi
- 1
Toru Nagasawa
- 1
Noriyuki Yanaka
- 1
Hideaki Yamada
- 1

1.Department of Agricultural ChemistryKyoto UniversityKyoto 606Japan