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Biotechnology Letters

, Volume 7, Issue 8, pp 557–562 | Cite as

Control of the aspartokinase ofStreptomyces noursei and its AEC-resistant mutants

  • F. Hänel
  • W. Friedrich
  • E. J. Bormann
  • U. Gräfe
Article

Summary

Addition of L-lysine to cultures ofS. noursei enhanced the production of nourseothricin. The aspartokinase of the wild-type strain was under concerted feedback inhibition by lysine plus threonine but was stimulated by lysine alone. Threonine in the medium increased the synthesis of enzyme. 10% of the mutants resistant to AEC showed a higher specific production of the antibiotic.

Keywords

Enzyme Organic Chemistry Lysine Bioorganic Chemistry Threonine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Science and Technology Letters 1985

Authors and Affiliations

  • F. Hänel
    • 1
  • W. Friedrich
    • 1
  • E. J. Bormann
    • 1
  • U. Gräfe
    • 1
  1. 1.Central Institute of Microbiology and Experimental TherapyG.D.R. Academy of SciencesJenaGDR

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