Virchows Archiv

, Volume 430, Issue 1, pp 77–82 | Cite as

Gynandroblastoma of the ovary: A case report with an immunohistochemical and ultrastructural study

  • Masaharu Fukunaga
  • Yasuhiko Endo
  • Shinichiro Ushigome
Case Report
Received:
Accepted:

Abstract

An ovarian gynandroblastoma in a 60-year-old woman is described. The cut-surface of the right ovary showed multiple macrofollicles separated by white fibrous tissues and multiple ill-defined yellowish nodules. The tumour consisted of substantial amount of a granulosa cell element and a Sertoli cell element with intermingled Leydig cells. Immunohistochemically, the tumour cells in both the granulosa cell and Sertoli cell elements were positive for cytokeratin CAM5.2. The granulòsa cell element showed strong membrane staining of Ewing's sarcoma antigen 013 and the Sertoli cell element was focally positive. Vimentin was observed in both the Sertoli cell element and the granulosa cells. Both elements and the Leydig cells were uniformly negative for epithelial membrane antigen, muscle specific actin, CD31 and CD34. The tumour was aneuploid by flow cytometry. The patient was well with no evidence of tumour five months after surgery.

Key words

Gynandroblastoma Granulosa cell tumour Sertoli cell tumour Leydig cell Crystal of Reinke 
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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • Masaharu Fukunaga
    • 1
  • Yasuhiko Endo
    • 1
  • Shinichiro Ushigome
    • 1
  1. 1.Department of PathologyThe Jikei University School of MedicineTokyoJapan

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