European Journal of Nuclear Medicine

, Volume 16, Issue 8–10, pp 649–655 | Cite as

99mTc-human immunoglobulin (HIG) — first results of a new agent for the localization of infection and inflammation

  • John R. Buscombe
  • Dominic Lui
  • Geert Ensing
  • Rolf de Jong
  • Peter J. Ell
Original Article


Technetium (99mTc) labelled, polyclonal human immunoglobulin (HIG) is a new agent that detects focal infection and inflammation. This new agent was compared in 40 patients with the accepted standard, namely111In-oxine-labelled leucocytes. This comparison resulted in a sensitivity of 94% and a specificity of 96% for99mTc-HIG when111In-oxine leucocytes were defined as giving the true result. The new agent was shown to localize both sepsis and active inflammatory bowel disease (IBD). There was 100% concordance in the 16 patients with IBD who were imaged with both99mTc-HIG and111In-oxine leucocytes. Discordant results were obtained in one case of suspected osteomyelitis, which was false-positive on the99mTc-HIG scan, and one case of pyrexia of unkown origin when the99mTc-HIG was false-negative and the111In-oxine leucocyte scan demonstrated accumulation of tracer in the caecum at 24 h post-injection. Normal distribution for99mTc-HIG demonstrated activity in the kidneys and bladder and that 50% of the tracer is cleared through the kidneys during the first 24 h post-injection. There were no major or minor side-effects.

Key words

99mTc-human immunoglobulin Polyclonal HIG Infection scanning Inflammatory bowel disease Osteomyelitis Pyrexia of unknown origin 


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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • John R. Buscombe
    • 1
  • Dominic Lui
    • 1
  • Geert Ensing
    • 2
  • Rolf de Jong
    • 2
  • Peter J. Ell
    • 1
  1. 1.Institute of Nuclear MedicineUniversity College and Middlesex School of MedicineLondonUK
  2. 2.Mallincrokdt DiagnosticaPettenThe Netherlands

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