Neurochemical Research

, Volume 17, Issue 9, pp 877–885

Quantitative aspects of reactive gliosis: A review

  • W. T. Norton
  • D. A. Aquino
  • I. Hozumi
  • F. -C. Chiu
  • C. F. Brosnan
Original Articles


Recent studies of gliosis in a variety of animal models are reviewed. The models include brain injury, neurotoxic damage, genetic diseases and inflammatory demyelination. These studies show that reactive gliosis is not a stereotypic response, but varies widely in duration, degree of hyperplasia, and time course of expression of GFAP immunostaining, content and mRNA. We conclude that there are different biological mechanisms for induction and maintenance of reactive gliosis, which, depending on the kind of tissue damage, result in different expressions of the gliotic response.

Key Words

Gliosis astrocytes GFAP brain damage demyelination 


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Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • W. T. Norton
    • 1
    • 2
  • D. A. Aquino
    • 1
  • I. Hozumi
    • 1
  • F. -C. Chiu
    • 1
    • 2
  • C. F. Brosnan
    • 2
    • 3
  1. 1.Department of NeurologyAlbert Einstein College of MedicineBronx
  2. 2.Department of NeuroscienceAlbert Einstein College of MedicineBronx
  3. 3.Department of PathologyAlbert Einstein College of MedicineBronx
  4. 4.Department of Neurology, Brain Research InstituteNiigata UniversityNiigataJapan

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