Advertisement

Molecular Biology Reports

, Volume 19, Issue 3, pp 201–210 | Cite as

Regulation of eukaryotic protein synthesis by protein kinases that phosphorylate initiation factor eIF-2

  • Michael J. Clemens
Special Issue: Protein Synthesis

Key words

amino acid starvation eIF-2B GCN4 guanine nucleotide exchange protein phosphorylation translational control 

Abbreviations

dsRNA

double-stranded RNA

eIF

eukaryotic initiation factor

HCR

haem controlled repressor

PKR

dsRNA-activated protein kinase

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Voorma H (1994) Mol. Biol. Rep. (in press — this volume)Google Scholar
  2. 2.
    Morley S (1994) Mol. Biol. Rep. (in press — this volume)Google Scholar
  3. 3.
    Pain VM (1986) Biochem. J. 235: 625–637PubMedGoogle Scholar
  4. 4.
    Hershey JWB (1989) J. Biol. Chem. 264: 20823–20826PubMedGoogle Scholar
  5. 5.
    Sarre TF (1989) Biosystems 22: 311–325PubMedGoogle Scholar
  6. 6.
    Hershey JWB (1991) Annu. Rev. Biochem. 60: 717–755PubMedGoogle Scholar
  7. 7.
    Proud CG (1992) Curr. Topics Cell Reg. 32: 243–369Google Scholar
  8. 8.
    Samuel CE (1993) J. Biol. Chem. 268: 7603–7606PubMedGoogle Scholar
  9. 9.
    Ernst H, Duncan RF & Hershey JWB (1987) J. Biol. Chem. 262: 1206–1212PubMedGoogle Scholar
  10. 10.
    Pathak VK, Nielsen P, Trachsel H & Hershey JWB (1988) Cell 54: 633–639PubMedGoogle Scholar
  11. 11.
    Hannig EM, Cigan AM, Freeman BA & Kinzy TG (1993) Mol. Cell. Biol. 13: 506–520PubMedGoogle Scholar
  12. 12.
    Matts RL, Thomas SB, Hurst R & London IM (1988) FEBS Lett. 236: 179–184PubMedGoogle Scholar
  13. 13.
    Gross M, Wing M, Rundquist C & Rubino MS (1987) J. Biol. Chem. 262: 6899–6907PubMedGoogle Scholar
  14. 14.
    Ramaiah KVA, Dhindsa RS, Chen J-J, London IM & Levin D (1992) Proc. Natl. Acad. Sci. USA 89: 12063–12067PubMedGoogle Scholar
  15. 15.
    Cigan AM, Bushman JL, Boal TR & Hinnebusch AG (1993) Proc. Natl. Acad. Sci. USA 90: 5350–5354PubMedGoogle Scholar
  16. 16.
    Rowlands AG, Panniers R & Henshaw EC (1988) J. Biol. Chem. 263: 5526–5533PubMedGoogle Scholar
  17. 17.
    Dholakia JN & Wahba AJ (1989) J. Biol. Chem. 264: 546–550PubMedGoogle Scholar
  18. 18.
    Boal TR, Chiorini JA, Cohen RB, Miyamoto S, Frederickson RM, Sonenberg N & Safer B (1993) Biochim. Biophys. Acta Mol. Cell Res. 1176: 257–264Google Scholar
  19. 19.
    Chiorini JA, Boal TR, Miyamoto S & Safer B (1993) J. Biol. Chem. 268: 13748–13755PubMedGoogle Scholar
  20. 20.
    Rosenwald IB, Rhoads DB, Callanan LD, Isselbacher KJ & Schmidt EV (1993) Proc. Natl. Acad. Sci. USA 90: 6175–6178PubMedGoogle Scholar
  21. 21.
    Jeffrey IW, Kelly FJ, Duncan R, Hershey JWB & Pain VM (1990) Biochimie 72: 751–757PubMedGoogle Scholar
  22. 22.
    Welsh GI & Proud CG (1992) Biochem. J. 284: 19–23PubMedGoogle Scholar
  23. 23.
    Welsh GI & Proud CG (1993) Biochem. J. 294: 625–629PubMedGoogle Scholar
  24. 24.
    Karinch AM, Kimball SR, Vary TC & Jefferson LS (1993) Am. J. Physiol. Endocrinol. Metab. 264: E101-E108Google Scholar
  25. 25.
    Dholakia JN & Wahba AJ (1988) Proc. Natl. Acad. Sci. USA 85: 51–54PubMedGoogle Scholar
  26. 26.
    Clemens MJ, Hershey JWB, Hovanessian AC, Jacobs BC, Katze MG, Kaufman RJ, Lengyel P, Samuel CE, Sen GC & Williams BRG (1993) J. Interferon Res. 13: 241–241PubMedGoogle Scholar
  27. 27.
    Meurs E, Chong K, Galabru J, Thomas NSB, Kerr IM, Williams BRG & Hovanessian AG (1990) Cell 62: 379–390PubMedGoogle Scholar
  28. 28.
    Chong KL, Feng L, Schappert K, Meurs E, Donahue TF, Friesen JD, Hovanessian AG & Williams BRG (1992) EMBO J. 11: 1553–1562PubMedGoogle Scholar
  29. 29.
    Chen J-J, Throop MS, Gehrke L, Kuo I, Pal JK, Brodsky M & London IM (1991) Proc. Natl. Acad. Sci. USA 88: 7729–7733PubMedGoogle Scholar
  30. 30.
    Dever TE, Chen J-J, Barber GN, Cigan AM, Feng L, Donahue TF, London IM, Katze MG & Hinnebusch AG (1993) Proc. Natl. Acad. Sci. USA 90: 4616–4620PubMedGoogle Scholar
  31. 31.
    Olmsted EA, O'Brien L, Henshaw EC & Panniers R (1993) J. Biol. Chem. 268: 12552–12559PubMedGoogle Scholar
  32. 32.
    Feldhoff RC, Karinch AM, Kimball SR & Jefferson LS (1993) Prep. Biochem. 23: 363–374PubMedGoogle Scholar
  33. 33.
    Barber GN, Tomita J, Garfinkel MS, Meurs E, Hovanessian A & Katze MG (1992) Virology 191: 670–679PubMedGoogle Scholar
  34. 34.
    Hiddinga HJ, Crum CJ, Hu J & Roth DA (1988) Science 241: 451–453PubMedGoogle Scholar
  35. 35.
    Sarre TF (1989) Biochem. J. 262: 569–574PubMedGoogle Scholar
  36. 36.
    Mellor H, Price NT, Oldfield S, Sarre TF & Proud CG (1993) Eur. J. Biochem. 211: 529–538PubMedGoogle Scholar
  37. 37.
    Pato MD, Adelstein RS, Crouch D, Safer B, Ingebritsen TS & Cohen P (1983) Eur. J. Biochem. 132: 283–287PubMedGoogle Scholar
  38. 38.
    Chen J-J, Pal JK, Petryshyn R, Kuo I, Yang JM, Throop MS, Gehrke L & London IM (1991) Proc. Natl. Acad. Sci. USA 88: 315–319PubMedGoogle Scholar
  39. 39.
    Méndez R, Moreno A & De Haro C (1992) J. Biol. Chem. 267: 11500–11507PubMedGoogle Scholar
  40. 40.
    Yang JM, London IM & Chen J-J (1992) J. Biol. Chem. 267: 20519–20524PubMedGoogle Scholar
  41. 41.
    Matts RL, Hurst R & Xu Z (1993) Biochemistry 32: 7323–7328PubMedGoogle Scholar
  42. 42.
    Matts RL, Xu Z, Pal JK & Chen J-J (1992) J. Biol. Chem. 267: 18160–18167PubMedGoogle Scholar
  43. 43.
    Duncan RF & Hershey JWB (1989) J. Cell Biol. 109: 1467–1481PubMedGoogle Scholar
  44. 44.
    Scorsone KA, Panniers R, Rowlands AG & Henshaw EC (1987) J. Biol. Chem. 262: 14538–14543PubMedGoogle Scholar
  45. 45.
    Sierra JM (1994) Mol. Biol. Rep. (in press — this volume)Google Scholar
  46. 46.
    Meurs EF, Watanabe Y, Kadereit S, Barber GN, Katze MG, Chong K, Williams BRG & Hovanessian AG (1992) J. Virol. 66: 5805–5814PubMedGoogle Scholar
  47. 47.
    Koromilas AE, Roy S, Barber GN, Katze MG & Sonenberg N (1992) Science 257: 1685–1689PubMedGoogle Scholar
  48. 48.
    Meurs EF, Galabru J, Barber GN, Katze MG & Hovanessian AG (1993) Proc. Natl. Acad. Sci. USA 90: 232–236PubMedGoogle Scholar
  49. 49.
    Clemens M (1992) Nature 360: 210–211PubMedGoogle Scholar
  50. 50.
    Lengyel P (1993) Proc. Natl. Acad. Sci. USA 90: 5893–5895PubMedGoogle Scholar
  51. 51.
    Thomis DC, Doohan JP & Samuel CE (1992) Virology 188: 33–46PubMedGoogle Scholar
  52. 52.
    Icely PL, Gros P, Bergeron JJM, Devault A, Afar DEH & Bell JC (1991) J. Biol. Chem. 266: 16073–16077PubMedGoogle Scholar
  53. 53.
    Patel RC & Sen GC (1992) J. Interferon Res. 12: 389–393PubMedGoogle Scholar
  54. 54.
    Baier LJ, Shors T, Shors ST & Jacobs BL (1993) Nucleic Acids Res. 21: 4830–4835PubMedGoogle Scholar
  55. 55.
    Jiménez-García LF, Green SR, Mathews MB & Spector DL (1993) J. Cell Sci. 106: 11–22PubMedGoogle Scholar
  56. 56.
    Galabru J & Hovanessian AG (1987) J. Biol. Chem. 262: 15538–15544PubMedGoogle Scholar
  57. 57.
    Lee SB & Esteban M (1993) Virology 193: 1037–1041PubMedGoogle Scholar
  58. 58.
    Barber GN, Wambach M, Wong M-L, Dever TE, Hinnebusch AG & Katze MG (1993) Proc. Natl. Acad. Sci. USA 90: 4621–4625PubMedGoogle Scholar
  59. 59.
    Thomis DC & Samuel CE (1992) Proc. Natl. Acad. Sci. USA 89: 10837–10841PubMedGoogle Scholar
  60. 60.
    Lee SB, Melkova Z, Yan W, Williams BRG, Hovanessian AG & Esteban M (1993) Virology 192: 380–385PubMedGoogle Scholar
  61. 61.
    Feng G, Chong K, Kumar A & Williams BRG (1992) Proc. Natl. Acad. Sci. USA 89: 5447–5451PubMedGoogle Scholar
  62. 62.
    Green SR & Mathews MB (1992) Genes Dev. 6: 2478–2490PubMedGoogle Scholar
  63. 63.
    Patel RC & Sen GC (1992) J. Biol. Chem. 267: 7671–7676PubMedGoogle Scholar
  64. 64.
    McCormack SJ, Thomis DC & Samuel CE (1992) Virology 188: 47–56PubMedGoogle Scholar
  65. 65.
    Barber GN, Tomita J, Hovanessian AG, Meurs E & Katze MG (1991) Biochemistry 30: 10356–10361PubMedGoogle Scholar
  66. 66.
    Katze MG, Wambach M, Wong M-L, Garfinkel M, Meurs E, Chong K, Williams BRG, Hovanessian AG & Barber GN (1991) Mol. Cell. Biol. 11: 5497–5505PubMedGoogle Scholar
  67. 67.
    St Johnston D, Brown NH, Gall JG & Jantsch M (1992) Proc. Natl. Acad. Sci. USA 89: 10979–10983PubMedGoogle Scholar
  68. 68.
    Chang H-W & Jacobs BL (1993) Virology 194: 537–547PubMedGoogle Scholar
  69. 69.
    Gatignol A, Buckler C & Jeang K-T (1993) Mol. Cell. Biol. 13: 2193–2202PubMedGoogle Scholar
  70. 70.
    Kostura M & Mathews MB (1989) Mol. Cell. Biol. 9: 1576–1586PubMedGoogle Scholar
  71. 71.
    Langland JO & Jacobs BL (1992) J. Biol. Chem. 267: 10729–10736PubMedGoogle Scholar
  72. 72.
    Manche L, Green SR, Schmedt C & Mathews MB (1992) Mol. Cell. Biol. 12: 5238–5248PubMedGoogle Scholar
  73. 73.
    Galabru J, Katze MG, Robert N & Hovanessian AG (1989) Eur. J. Biochem. 178: 581–589PubMedGoogle Scholar
  74. 74.
    Sharp TV, Schwemmle M, Jeffrey I, Laing K, Mellor H, Proud CG, Hilse K & Clemens MJ (1993) Nucleic Acids Res. 21: 4483–4490PubMedGoogle Scholar
  75. 75.
    Sharp TV, Xiao Q, Jeffrey I, Gewert DR & Clemens MJ (1993) Eur. J. Biochem. 214: 945–948PubMedGoogle Scholar
  76. 76.
    Li J & Petryshyn RA (1991) Eur. J. Biochem. 195: 41–48PubMedGoogle Scholar
  77. 77.
    Pratt G, Galpine A, Sharp N, Palmer S & Clemens MJ (1988) Nucleic Acids Res. 16: 3497–3510PubMedGoogle Scholar
  78. 78.
    Barber GN, Edelhoff S, Katze MG & Disteche CM (1993) Genomics 16: 765–767PubMedGoogle Scholar
  79. 79.
    Squire J, Meurs EF, Chong KL, McMillan NAJ, Hovanessian AG & Williams BRG (1993) Genomics 16: 768–770PubMedGoogle Scholar
  80. 80.
    Hinnebusch AG (1990) Trends Biochem. Sci. 15: 148–152PubMedGoogle Scholar
  81. 81.
    Ramirez M, Wek RC & Hinnebusch AG (1991) Mol. Cell. Biol. 11: 3027–3036PubMedGoogle Scholar
  82. 82.
    Dever TE, Feng L, Wek RC, Cigan AM, Donahue TF & Hinnebusch AG (1992) Cell 68: 585–596PubMedGoogle Scholar
  83. 83.
    Wek RC, Ramirez M, Jackson BM & Hinnebusch AG (1990) Mol. Cell. Biol. 10: 2820–2831PubMedGoogle Scholar
  84. 84.
    Ramirez M, Wek RC, Vazquez de Aldana CR, Jackson BM, Freeman B & Hinnebusch AG (1992) Mol. Cell. Biol. 12: 5801–5815PubMedGoogle Scholar
  85. 85.
    Krupitza G & Thireos G (1990) Mol. Cell. Biol. 10: 4375–4378PubMedGoogle Scholar
  86. 86.
    Marton MJ, Crouch D & Hinnebusch AG (1993) Mol. Cell. Biol. 13: 3541–3556PubMedGoogle Scholar
  87. 87.
    Rolfes RJ & Hinnebusch AG (1993) Mol. Cell. Biol. 13: 5099–5111PubMedGoogle Scholar
  88. 88.
    Colthurst DR, Campbell DG & Proud CG (1987) Eur. J. Biochem. 166: 357–363PubMedGoogle Scholar
  89. 89.
    Choi S-Y, Scherer BJ, Schnier J, Davies MV, Kaufman RJ & Hershey JWB (1992) J. Biol. Chem. 267: 286–293PubMedGoogle Scholar
  90. 90.
    Murtha-Riel P, Davies MV, Scherer BJ, Choi S-Y, Hershey JWB & Kaufman RJ (1993) J. Biol. Chem. 268: 12946–12951PubMedGoogle Scholar
  91. 91.
    Kaufman RJ, Davies MV, Pathak VK & Hershey JWB (1989) Mol. Cell. Biol. 9: 946–958PubMedGoogle Scholar
  92. 92.
    Vazquez de Aldana CR, Dever TE & Hinnebusch AG (1993) Proc. Natl. Acad. Sci. USA 90: 7215–7219PubMedGoogle Scholar
  93. 93.
    Hannig EM, Williams NP, Wek RC & Hinnebusch AG (1990) Genetics 126: 549–562PubMedGoogle Scholar
  94. 94.
    Foiani M, Cigan AM, Paddon CJ, Harashima S & Hinnebusch AG (1991) Mol. Cell. Biol. 11: 3203–3216PubMedGoogle Scholar
  95. 95.
    Cigan AM, Foiani M, Hannig EM & Hinnebusch AG (1991) Mol. Cell. Biol. 11: 3217–3228PubMedGoogle Scholar
  96. 96.
    Bushman JL, Asuru AI, Matts RL & Hinnebusch AG (1993) Mol. Cell. Biol. 13: 1920–1932PubMedGoogle Scholar
  97. 97.
    Bushman JL, Foiani M, Cigan AM, Paddon CJ & Hinnebusch AG (1993) Mol. Cell. Biol. 13: 4618–4631PubMedGoogle Scholar
  98. 98.
    Katze MG (1992) J. Interferon Res. 12: 241–248PubMedGoogle Scholar
  99. 99.
    Mathews MB & Shenk T (1991) J. Virol. 65: 5657–5662PubMedGoogle Scholar
  100. 100.
    Clarke PA, Schwemmle M, Schickinger J, Hilse K & Clemens MJ (1991) Nucleic Acids Res. 19: 243–248PubMedGoogle Scholar
  101. 101.
    Ghadge GD, Swaminathan S, Katze MG & Thimmapaya B (1991) Proc. Natl. Acad. Sci. USA 88: 7140–7144PubMedGoogle Scholar
  102. 102.
    Watson JC, Chang H-W & Jacobs BL (1991) Virology 185: 206–216PubMedGoogle Scholar
  103. 103.
    Chang H-W, Watson JC & Jacobs BL (1992) Proc. Natl. Acad. Sci. USA 89: 4825–4829PubMedGoogle Scholar
  104. 104.
    Miller JE & Samuel CE (1992) J. Virol. 66: 5347–5356PubMedGoogle Scholar
  105. 105.
    Davies MV, Chang H-W, Jacobs BL & Kaufman RJ (1993) J. Virol. 67: 1688–1692PubMedGoogle Scholar
  106. 106.
    Black T, Safer B, Hovanessian A & Katze MG (1989) J. Virol. 63: 2244–2252PubMedGoogle Scholar
  107. 107.
    Roy S, Katze MG, Parkin NT, Edery I, Hovanessian AG & Sonenberg N (1990) Science 247: 1216–1219PubMedGoogle Scholar
  108. 108.
    Judware R, Li J & Petryshyn R (1993) J. Interferon Res. 13: 153–160PubMedGoogle Scholar
  109. 109.
    Davies MV, Elroy-Stein O, Jagus R, Moss B & Kaufman RJ (1992) J. Virol. 66: 1943–1950PubMedGoogle Scholar
  110. 110.
    Carroll K, Elroy-Stein O, Moss B & Jagus R (1993) J. Biol. Chem. 268: 12837–12842PubMedGoogle Scholar
  111. 111.
    Mundschau LJ & Faller DV (1992) J. Biol. Chem. 267: 23092–23098PubMedGoogle Scholar
  112. 112.
    Lee TG, Tomita J, Hovanessian AG & Katze MG (1990) Proc. Natl. Acad. Sci. USA 87: 6208–6212PubMedGoogle Scholar
  113. 113.
    Judware R & Petryshyn R (1991) Mol. Cell. Biol. 11: 3259–3267PubMedGoogle Scholar
  114. 114.
    Saito S & Kawakita M (1991) Microbiol. Immunol. 35: 1105–1114PubMedGoogle Scholar
  115. 115.
    Lee TG, Tomita J, Hovanessian AG & Katze MG (1992) J. Biol. Chem. 267: 14238–14243PubMedGoogle Scholar
  116. 116.
    Judware R & Petryshyn R (1992) J. Biol. Chem. 267: 21685–21690PubMedGoogle Scholar
  117. 117.
    Ray MK, Datta B, Chakraborty A, Chattopadhyay A, Meza-Keuthen S & Gupta NK (1992) Proc. Natl. Acad. Sci. USA 89: 539–543PubMedGoogle Scholar
  118. 118.
    Ray MK, Chakraborty A, Datta B, Chattopadhyay A, Saha D, Bose A, Kinzy TG, Wu S, Hileman RE, Merrick WC & Gupta NK (1993) Biochemistry 32: 5151–5159PubMedGoogle Scholar
  119. 119.
    Wu S, Gupta S, Chatterjee N, Hileman RE, Kinzy TG, Denslow ND, Merrick WC, Chakrabarti D, Osterman JC & Gupta NK (1993) J. Biol. Chem. 268: 10796–10801PubMedGoogle Scholar
  120. 120.
    Montine KS & Henshaw EC (1989) Biochim. Biophys. Acta 1014: 282–288PubMedGoogle Scholar
  121. 121.
    Mahadevan LC, Wills AJ, Hirst EA, Rathjen PD & Heath JK (1990) Oncogene 5: 327–335PubMedGoogle Scholar
  122. 122.
    Petryshyn R, Chen J-J & London IM (1984) J. Biol. Chem. 259: 14736–14742PubMedGoogle Scholar
  123. 123.
    Petryshyn R, Chen J-J & London IM (1988) Proc. Natl. Acad. Sci. USA 85: 1427–1431PubMedGoogle Scholar
  124. 124.
    Chinchar VG & Dholakia JN (1989) Virus Res. 14: 207–224PubMedGoogle Scholar
  125. 125.
    Huang J & Schneider RJ (1990) Proc. Natl. Acad. Sci. USA 87: 7115–7119PubMedGoogle Scholar
  126. 126.
    DeStefano J, Olmsted E, Panniers R & Lucas-Lenard J (1990) J. Virol. 64: 4445–4453PubMedGoogle Scholar
  127. 127.
    Kaufman RJ & Murtha P (1987) Mol. Cell. Biol. 7: 1568–1571PubMedGoogle Scholar
  128. 128.
    Farrell PJ, Balkow K, Hunt T, Jackson RJ & Trachsel H (1977) Cell 11: 187–200PubMedGoogle Scholar
  129. 129.
    Leroux A & London IM (1982) Proc. Natl. Acad. Sci. USA 79: 2147–2151PubMedGoogle Scholar
  130. 130.
    Davies MV, Furtado M, Hershey JWB, Thimmappaya B & Kaufman RJ (1989) Proc. Natl. Acad. Sci. USA 86: 9163–9167PubMedGoogle Scholar
  131. 131.
    Rowlands AG, Montine KS, Henshaw EC & Panniers R (1988) Eur. J. Biochem. 175: 93–99PubMedGoogle Scholar
  132. 132.
    Mundschau LJ & Faller DV (1991) Mol. Cell. Biol. 11: 3148–3154PubMedGoogle Scholar
  133. 133.
    Clemens MJ, Galpine A, Austin SA, Panniers R, Henshaw EC, Duncan R, Hershey JWB & Pollard JW (1987) J. Biol. Chem. 262: 767–771PubMedGoogle Scholar
  134. 134.
    Altmann M & Trachsel H (1993) Trends Biochem. Sci. 18: 429–432PubMedGoogle Scholar
  135. 135.
    Miller PF & Hinnebusch AG (1990) Biochim. Biophys. Acta Gene Struct.Expression 1050: 151–154Google Scholar
  136. 136.
    Abastado J-P, Miller PF, Jackson BM & Hinncbusch AG (1991) Mol. Cell. Biol. 11: 486–496PubMedGoogle Scholar
  137. 137.
    Tzamarias D, Roussou I & Thireos G (1989) Cell 57: 947–954PubMedGoogle Scholar
  138. 138.
    Williams NP, Hinnebusch AG & Donahue TF (1989) Proc. Natl. Acad. Sci. USA 86: 7515–7519PubMedGoogle Scholar
  139. 139.
    Wek RC, Cannon JF, Dever TE & Hinnebusch AG (1992) Mol. Cell. Biol. 12: 5700–5710PubMedGoogle Scholar
  140. 140.
    Lanker S, Bushman JL, Hinnebusch AG, Trachsel H & Mueller PP (1992) Cell 70: 647–657PubMedGoogle Scholar
  141. 141.
    Donahue TF, Cigan AM, Pabich EK & Valavicius BC (1988) Cell 54: 621–632PubMedGoogle Scholar
  142. 142.
    Dasso MC, Milburn SC, Hershey JWB & Jackson RJ (1990) Eur. J. Biochem. 187: 361–371PubMedGoogle Scholar
  143. 143.
    Pollard JW, Galpine AR & Clemens MJ (1989) Eur. J. Biochem. 182: 1–9PubMedGoogle Scholar
  144. 144.
    Clemens MJ (1990) Trends Biochem. Sci. 15: 172–175PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1994

Authors and Affiliations

  • Michael J. Clemens
    • 1
  1. 1.Division of Biochemistry, Department of Cellular and Molecular SciencesSt George's Hospital Medical School, Cranmer TerraceLondonUK

Personalised recommendations