Neurochemical Research

, Volume 13, Issue 7, pp 649–655

Monomeric and polymeric forms of ependymin: A brain extracellular glycoprotein implicated in memory consolidation processes

  • Victor E. Shashoua
Original Articles

Abstract

Ependymin, a brain extracellular glycoprotein that appears to be implicated in neural circuit modifications associated with the process of memory consolidation, can rapidly polymerize into fibrous aggregates when the Ca2+ concentration in solution is reduced by the addition of EGTA or by dialysis. Such aggregates, once formed, could not be redissolved in boiling 1% SDS in 6 M urea, acetic acid, saturated aqueous potassium thiocyanate, and trifluoroacetic acid. They were, however, soluble in formic acid. Investigations of the immunological properties of ependymin indicated that various monomers, oligomers and polymers of the molecule with differing carbohydrate contents can be obtained. The polymerization properties of the ependymins may play an important role in their functions in memory consolidation mechanisms.

Key Words

Ependymin brain extracellular fluid glycoproteins extracellular matrix memory consolidation 

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Copyright information

© Plenum Publishing Corporation 1988

Authors and Affiliations

  • Victor E. Shashoua
    • 1
  1. 1.Ralph Lowell Laboratories, McLean HospitalHarvard Medical SchoolBelmont

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