Neurochemical Research

, Volume 12, Issue 9, pp 767–774 | Cite as

Is all cyclo(His-Pro) derived from thyrotropin-releasing hormone?

  • Chandan Prasad
  • A. Jayaraman
  • Hugh J. F. Robertson
  • Jayashree K. Rao
Overview
Accepted:

Abstract

Cyclo(His-Pro), or histidyl-proline diketopiperazine, is an endogenous cyclic dipeptide that is ubiquitously distributed in tissues and body fluids of both man and animals. This cyclic dipeptide is not only structurally related to thyrotropin-releasing hormone (TRH, pGlu-His-ProNH2), but it can also arise from TRH by the action of the enzyme pyroglutamate amino-peptidase (pGlu-peptidase). The data on the distribution of TRH, cyclo(His-Pro), and pGlu-peptidase under normal and abnormal conditions are summarized and potential relationships analyzed. We conclude that all of the cyclo(His-Pro) cannot be derived from TRH. Two additional sources of cyclo(His-Pro) are suggested. It is proposed that 29,247 molecular weight TRH prohormone, prepro TRH, which contains 5 copies of TRH sequence, can be processed to yield cyclo(His-Pro). Thus, both TRH and cyclo(His-Pro) share a common precursor, prepro[TRH/Cyclo(His-Pro)].

Key Words

Cyclo(His-Pro) TRH 
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Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • Chandan Prasad
    • 1
  • A. Jayaraman
    • 2
  • Hugh J. F. Robertson
    • 3
  • Jayashree K. Rao
    • 4
  1. 1.Department of Medicine (Section of Endocrinology)Louisiana State University Medical CenterNew Orleans
  2. 2.Department of NeurologyLouisiana State University Medical CenterNew Orleans
  3. 3.Department of RadiologyLouisiana State University Medical CenterNew Orleans
  4. 4.Department of PediatricsLouisiana State University Medical CenterNew Orleans

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