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Neurochemical Research

, Volume 17, Issue 10, pp 983–990 | Cite as

Sigma receptors in schizophrenic cerebral cortices

  • Haruo Shibuya
  • Hiroshi Mori
  • Michio Toru
Original Articles

Abstract

Antipsychotics represent high affinity for sigma receptors and sigma-like drugs often have the psychotomimetic properties. Besides, the receptors are unevenly distributed in human brain. These findings suggest that sigma receptors might be involved in the pathophysiology of schizophrenia. Sigma receptors in rat and human brain were measured with [3H]-1, 3, di-o-tolylguanidine (DTG) and non-specific binding of [3H]DTG was determined in the presence of 10−5M haloperidol. Monovalent and divalent cations strongly inhibited [3H]DTG binding. Glutamate, aspartate and glycine also decreased the binding to human cerebral membranes. With post-mortem brain samples from 12 schizophrenics and 10 controls, sigma receptors were measured in 17 areas of cerebral cortex. Sigma receptors binding showed the regional differences in the cortex, but no significant differences between schizophrenics and controls were observed except the superior parietal cortex where the binding significantly increased in the schizophrenic group. These results suggest that sigma receptors in cerebral cortices might not be directly concerned with the pathophysiological role in schizophrenia.

Key Words

Sigma receptor [3H]DTG receptor binding schizophrenic cerebral cortex rat brain amino acids 

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Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • Haruo Shibuya
    • 1
  • Hiroshi Mori
    • 1
  • Michio Toru
    • 1
  1. 1.Department of NeuropsychiatryTokyo Medical and Dental UniversityBunkyo-ku, TokyoJapan

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