Neurochemical Research

, Volume 3, Issue 6, pp 815–820 | Cite as

Cholinergic systems in muscle and brain in vitamin E-deficient rats

  • S. C. Sung
  • P. R. Sanberg
  • E. G. McGeer
Original Articles
Accepted:

Abstract

Rats fed a vitamin E-deficient diet for 7–8 weeks postweaning showed no change in brain weight or the activity in brain of various enzymes involved in neurotransmitter synthesis and metabolism. Body and muscle weights were markedly reduced. Muscle choline acetyltransferase and acetylcholinesterase activities were significantly elevated on a protein basis, but the total amount of choline acetyltransferase/muscle was essentially normal and total acetylcholinesterase activity was slightly reduced. Total carnitine acetyltransferase and butyrylcholinesterase activities were markedly decreased. The results are quite different from those found in hereditary murine muscular dystrophy and suggest a myogenic etiology for the vitamin E-deficiency-induced condition.

Keywords

Choline Carnitine Muscular Dystrophy Acetylcholinesterase Protein Basis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • S. C. Sung
    • 1
  • P. R. Sanberg
    • 1
  • E. G. McGeer
    • 1
  1. 1.Kinsmen Laboratory of Neurological Research Department of PsychiatryUniversity of British ColumbiaVancouverCanada

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