Neurochemical Research

, Volume 11, Issue 8, pp 1139–1149 | Cite as

Genetic determination of striatal tyrosine hydroxylase activity in mice

  • Csaba Vadász
  • Istvan Sziráki
  • Leelavati R. Murthy
  • Abel Lajtha
Original Articles
Accepted:

Abstract

An additive major gene effect is described for tyrosine hydroxylase activity in mouse corpus striatum (CS). Quantitative genetic analysis indicated the presence of a segregating Mendelian factor with robust additive effect in F2 generations derived from crossing two highly inbred mouse strains, C57BL/6ByJ and BALB/ cJ, with intermediate (INT) and high (HI) TH activity in CS. Significant positive correlation was found between striatal and mesencephalic TH activity in the segregating generations, raising the possiblity that a common single gene may express its effect through pleiotropy or linkage. Genetic preparations taking advantage of the major gene effect should serve well as animal models of DA-mediated neuropsychiatric disorders.

Keywords

Tyrosine Genetic Analysis Single Gene Significant Positive Correlation Mouse Strain 
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Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • Csaba Vadász
    • 1
  • Istvan Sziráki
    • 1
  • Leelavati R. Murthy
    • 1
  • Abel Lajtha
    • 2
  1. 1.Laboratory of Neurobehavioral Genetics Neurochemistry DivisionNathan S. Kline Institute for Psychiatric ResearchOrangeburg
  2. 2.Center for NeurochemistryNathan Kline Institute Ward's IslandNew York

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