Neurochemical Research

, Volume 10, Issue 8, pp 1019–1024 | Cite as

Inhibition of polyphosphoinositide phosphodiesterase by aminoglycoside antibiotics

  • Lucio A. A. Van Rooijen
  • Bernard W. Agranoff
Original Articles
Accepted:

Abstract

The calcium-activated phosphodiesteratic hydrolysis of32P-labeled phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate in prelabeled nerve ending membranes is inhibited by the aminoglycosides neomycin and gentamicin, and to a lesser extent, by streptomycin. The inhibition is overcome by increasing concentrations of Ca2+, indicating that the aminoglycosides exert their effect by displacing Ca2+ from lipid.

Keywords

Lipid Streptomycin Gentamicin Aminoglycosides Phosphodiesterase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Lucio A. A. Van Rooijen
    • 1
  • Bernard W. Agranoff
    • 1
  1. 1.Neuroscience Laboratory Mental Health Research InstituteThe University of MichiganAnn Arbor

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