Neurochemical Research

, Volume 9, Issue 2, pp 219–224 | Cite as

Inhibition by N-acetyl-aspartate of aspartate binding to a proteolipid fraction from rat cerebral cortex

  • M. Burgal
  • J. Lizondo
  • A. Jordá
  • S. Grisolía
Original Articles


Many roles have been suggested for N-acetyl-aspartate in brain function because of it being located almost exclusively in that organ. However, its true role remains to be demonstrated. We show here that N-acetyl-aspartate: 1) binds to a hydrophobic protein fraction from the cerebral cortex of the rat, which specifically bindsl-aspartate,l-glutamate, and γ-amino-butyric acid; and 2) has a marked inhibitory effect on the aspartate binding sites of this proteolipid fraction. Structural analogs of N-acetyl-asparate, i.e. N-carbamyl-aspartate and N-methyl-aspartate also inhibit thel-aspartate binding by the brain protein fraction used.


Aspartate Binding Site Cerebral Cortex Brain Function Protein Fraction 
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Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • M. Burgal
    • 1
  • J. Lizondo
    • 1
  • A. Jordá
    • 1
  • S. Grisolía
    • 1
  1. 1.Instituto de Investigaciones Citológicas de la Caja de Ahorros de ValenciaValenciaSpain

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