Acidity of methyl substituents in pyrazole ring

  • A. N. Sinyakov
  • M. S. Shvartsberg
Brief Communications
Received:

Conclusions

  1. 1.

    In liquid NH3 the acidity of the methyl group in the 5 position of 4-phenylethynyl-1,5-dimethylpyrazole is close to the acidity of the methyl group ofα-picoline.

     
  2. 2.

    The direction of the metalation of 4-phenylethynyl-1,5-dimethylpyrazole depends on the nature of the solvent and the metalating agent.

     

Keywords

Methyl Acidity Pyrazole Methyl Substituent Metalating Agent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Literature cited

  1. 1.
    M. S. Shvartsberg, S. F. Vasilevskii, and A. N. Sinyakov, Izv. Akad. Nauk SSSR, Ser. Khim.,1976, 2292.Google Scholar
  2. 2.
    K. Sonogashira, Y. Tohda, and N. Hagihara, Tetrahedron Lett.,1975, 4467.Google Scholar
  3. 3.
    C. E. Castro and R. D. Stephens, J. Org. Chem.,28, 2163 (1963).Google Scholar
  4. 4.
    J. A. Zoltewicz and L. S. Helmick, J. Org. Chem.,38, 658 (1973).Google Scholar
  5. 5.
    R. G. Micetich, Can. J. Chem.,48, 2006 (1970).Google Scholar

Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • A. N. Sinyakov
    • 1
  • M. S. Shvartsberg
    • 1
  1. 1.Institute of Chemical Kinetics and CombustionSiberian Branch of the Academy of Sciences of the USSRNovosibirsk

Personalised recommendations