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Journal of Computational Neuroscience

, Volume 2, Issue 4, pp 291–298 | Cite as

Pyramidal cell-to-inhibitory cell spike transduction explicable by active dendritic conductances in inhibitory cell

  • Roger D. Traub
  • Richard Miles
Article

Abstract

In the guinea-pig hippocampal CA3 region, the synaptic connection from pyramidal neurons tostratum pyramidale inhibitory neurons is remarkable. Anatomically, the connection usually consists of a single release site on an interneuronal dendrite, sometimes 200 μm or more from the soma. Nevertheless, the connection is physiologically powerful, in that a single presynaptic action potential can evoke, with probability 0.1 to 0.6, a postsynaptic action potential with latency 2 to 6 ms. We construct a model interneuron and show that the anatomical and physiological observations can be reconciled if the interneuron dendrites are electrically excitable. Excitable dendrites could also account for depolarization-induced amplification of the pyramidal cell-interneuron EPSP in the voltage range subthreshold for spike generation.

Keywords

recurrent excitation synaptic integration dendritic electrogenesis 

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Copyright information

© Kluwer Academic Publishers 1995

Authors and Affiliations

  • Roger D. Traub
    • 1
    • 2
  • Richard Miles
    • 3
  1. 1.IBM Research DivisionT.J. Watson Research CenterYorktown HeightsUSA
  2. 2.Department of NeurologyColumbia UniversityNew YorkUSA
  3. 3.Institut PasteurParis Cedex 15France

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