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Molecular and Cellular Biochemistry

, Volume 147, Issue 1–2, pp 77–81 | Cite as

Oxidative stress and heart failure

  • Neelam Singh
  • Arvinder K. Dhalla
  • Charita Seneviratne
  • Pawan K. Singal
Part II: Myocytic Adaptation and Myocardial Injury

Abstract

Various abnormalities have been implicated in the transition of hypertrophy to heart failure but the exact mechanism is still unknown. Thus heart failure subsequent to hypertrophy remains a major clinical problem. Recently, oxidative stress has been suggested to play a critical role in the pathogenesis of heart failure. Here we describe antioxidant changes as well as their significance during hypertrophy and heart failure stages. Heart hypertrophy in rats and guinea pigs, in response to pressure over-load, is associated with an increase in ‘antioxidant reserve’ and a decrease in oxidative stress. Hypertrophied rat hearts show increased tolerance for different oxidative stress conditions such as those imposed by free radicals, hypoxia-reoxygenation and ischemia-reperfusion. On the other hand, heart failure under acute as well as chronic conditions is associated with reduced antioxidant reserve and increased oxidative stress. The latter may have a causal role as suggested by the protection seen with antioxidant treatment in acute as well as in chronic heart failure. It is becoming increasingly apparent that, anytime the available antioxidant reserve in the cell becomes inadequate, myocardial dysfunction is imminent.

Key words

antioxidants redox state lipid peroxidation 

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References

  1. 1.
    Singal PK, Kirshenbaum LA: A relative deficit in antioxidant reserve may contribute in cardiac failure. Can J Cardiol 6: 47–49, 1990PubMedGoogle Scholar
  2. 2.
    Kaul N, Siveski-Iliskovic N, Hill M, Slezák J, Singal PK: Free radicals and the heart. J Pharmacol Toxicol Meth 30: 55–67, 1993Google Scholar
  3. 3.
    Curello S, Ceconi C, Bigoli C, Ferrari R, Albertini A, Guarnien C: Change in the cardiac glutathione after ischemia and reperfusion. Experimentia 41: 42–43, 1985Google Scholar
  4. 4.
    Ferrari R, Ceconi C, Curello S, Guarnieri C, Caldarera CM, Albertini A, Visioli O: Oxygen-mediated myocardial damage during ischemia and reperfusion: role of the cellular defenses against oxygen toxicity. J Mol Cell Cardiol 17: 937–945, 1985PubMedGoogle Scholar
  5. 5.
    Guarnieri C, Flamigni F, Caldarera CM: Role of oxygen in cellular damage induced by reoxygenation of hypoxic heart. J Mol Cell Cardiol 12: 797–808, 1980PubMedGoogle Scholar
  6. 6.
    Dhaliwal H, Kirschenbaum LA, Randhawa AK, Singal PK: Correlation between antioxidant changes during hypoxia and recovery upon reoxygenation. Am J Physiol 261: H632-H638, 1991PubMedGoogle Scholar
  7. 7.
    Dhalla AK, Singal PK: Antioxidant changes in hypertrophied and failing guinea pig hearts. Am J Physiol 266 (Heart Circ Physiol): H1280-H1285, 1994PubMedGoogle Scholar
  8. 8.
    Singal PK, Dhalla AK, Hill M, Thomas TP: Endogenous antioxidant changes in the myocardium in response to acute and chronic stress conditions. Mol Cell Biochem 129: 179–186, 1993PubMedGoogle Scholar
  9. 9.
    Gupta M, Singal PK: Higher antioxidative capacity during a chronic stable heart hypertrophy. Circ Res 64: 398–406, 1989PubMedGoogle Scholar
  10. 10.
    Higuchi M, Cartier LJ, Chen M, Holloszy JO: Superoxide dismutase and catalase in skeletal muscle: adaptive response to exercise. J Gerontology 40: 281–286, 1985Google Scholar
  11. 11.
    Kanter MM, Hamlin RL, Unverferth DV, Davis HW, Merola AJ: Effect of exercise training on antioxidant enzymes and cardiotoxicity of doxorubicin. J Appl Physiol 59: 1298–1303, 1985PubMedGoogle Scholar
  12. 12.
    Kirshenbaum LA, Singal PK: Antioxidant changes in heart hypertrophy: significance during hypoxia-reoxygenation injury. Can J Physiol Pharmacol 70: 1330–1335, 1992PubMedGoogle Scholar
  13. 13.
    Kirshenbaum LA, Singal PK: Increase in endogenous antioxidant enzymes protects the heart against reperfusion injury. Am J Physiol 265: H484-H493, 1993PubMedGoogle Scholar
  14. 14.
    Kirshenbaum LA, Hill M, Singal PK: Endogenous antioxidants in isolated hypertrophied cardiac myocytes and hypoxia-reoxygenation injury. J Mol Cell Cardiol 27: 263–272, 1995PubMedGoogle Scholar
  15. 15.
    Randhawa, AK, Singal PK: Pressure overload-induced cardiac hypertrophy with and without dilation. J Am Coll Cardiol 20: 1569–1575, 1992PubMedGoogle Scholar
  16. 16.
    Singal PK, Deally CMR, Weinberg LE: Subcellular effects of adriamycin in the heart: a concise review. J Mol Cell Cardiol 19: 817–828, 1987PubMedGoogle Scholar
  17. 17.
    Siveski-Iliskovic N, Kaul N, Singal PK Probucol promotes endogenous antioxidants and provides protection against adriamycin-induced cardiomyopathy in rats. Circulation 89: 2829–2835, 1994PubMedGoogle Scholar
  18. 18.
    Kirshenbaum LA, Singal PK: Changes in antioxidant enzymes in isolated cardiac myocytes subjected to hypoxia-reoxygenation. Lab Invest 67 (6): 796–803, 1992PubMedGoogle Scholar
  19. 19.
    Ferrari R, Curello S, Ceconi C, Cargnoni A, Condorelli E, Albertini A: Alterations of glutathione status during myocardial ischemia and reperfusion. In: P.K. Singal (ed). Oxygen Radicals in the Pathophysiology of Heart Disease. Kluwer Academic Press, Massachussets, 1988 pp 145–160Google Scholar
  20. 20.
    Siveski-Iliskovic N, Hill M, Chow DA, Singal PK: Probucol protects against adriamycin cardiomyopathy without interfering with its antitumor effect. Circulation 1995 (in press)Google Scholar
  21. 21.
    Guarnieri C, Muscari C, Caldarera CM, Slefanelli C, Pretolani E: The effect of treatment with coenzyme Q10 on the mitochondrial function and superoxide radical formation in cardiac muscle hypertrophied by mild stenosis. J Mol Cell Cardiol 19: 63–71, 1985Google Scholar
  22. 22.
    Kobayashi A, Yamashita T, Kaneko M, Nishiyama T, Hayashi H, Yamaszaki N: Effect of verapamil on experimental cardiomyopathy in the bio 14.6 Syrian hamster. J Am Coll Cardiol 10: 1128–1134, 1987PubMedGoogle Scholar
  23. 23.
    Werns SW, Lucchesi BR: The role of the polymorphonuclear leukocyte in mediating myocardial reperfusion injury. In: P.K. Singal (ed). Oxygen Radicals in the Pathophysiology of Heart Disease. Kluwer Academic Press, Massachussets, 1988, pp 123–144Google Scholar
  24. 24.
    Janero DR: Therapeutic potential of vitamin E against myocardial ischemia-reperfusion injury. Free Rad Biol Med 10: 315–324, 1991PubMedGoogle Scholar
  25. 25.
    van Acker SABE, Koymans LMH, Bast A: Molecular pharmacology of vitamin E: structural aspects of antioxidant activity. Free Rad Biol Med 15: 311–328, 1993PubMedGoogle Scholar
  26. 26.
    Dhalla AK, Singal PK: Vitamin E delays pathogenesis of heart failure due to chronic pressure overload. Can J Cardiology 10(A): 72A, 1994Google Scholar
  27. 27.
    Dhalla AK, Singh N, Singal PK: Antioxidant therapy associated with the reversal of oxidative stress, delays the pathogenesis of heart failure. Circulation 1995 (in press)Google Scholar
  28. 28.
    Packer L: Vitamin E is nature's master antioxidant. Scientific American Science and Medicine 1: 54–63, 1994Google Scholar
  29. 29.
    Massey KD, Burton KP: Alpha-tocopherol attenuates myocardial membrane-related alterations resulting from ischemia and reperfusion. Am J Physiol 256: H1192-H1199, 1989PubMedGoogle Scholar
  30. 30.
    Ferrari R, Visiolo O, Guarnieri C, Caldarera M: Vitamin E and the heart: possible role as antioxidant. Acta Vitaminol Enzymol 5: 11–22, 1983PubMedGoogle Scholar
  31. 31.
    Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC: Vitamin E consumption and the risk of coronary disease in men. N Eng J Med 328: 1450–1456, 1993Google Scholar
  32. 32.
    Stampfer MJ, Hennekens CN, Manson JE, Colditz GA, Rosner B, Willett WC: Vitamin E consumption and the risk of coronary disease in women. N Eng J Med 328: 1444–1449, 1993Google Scholar
  33. 33.
    Mickle DAG, Li RK, Weisel RD, Birnbaum PL, Wu TW, Jackawski G, Madonik MM, Burton GW, Ingold KU: Myocardial salvage with Trolox and ascorbic acid for an acute evolving infarction. Ann Thorac Surg 47: 553–557, 1989PubMedGoogle Scholar
  34. 34.
    Rosenfeld W, Evans H, Jhaveri R, Moainie H, Vohra K, Georgatos E, Salazar JD: Safety and plasma concentrations of bovine superoxide dismutase administered to human premature infants. Dev Pharmacol Ther 5: 151–161, 1982PubMedGoogle Scholar
  35. 35.
    Iarema NI, Konovalova GG, Lankin VZ: Changes in the activity of antioxidant enzymes in patients with hypertension. Kardiologia 32(3): 46–48, 1992Google Scholar
  36. 36.
    Ceriello A, Giugliano D, Quatraro A, Lefebvre PJ: Antioxidants show an antihypertensive effect in diabetic and hypertensive subjects. Clin Sci Colch 81(6): 739–742, 1991PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1995

Authors and Affiliations

  • Neelam Singh
    • 1
    • 2
  • Arvinder K. Dhalla
    • 1
    • 2
  • Charita Seneviratne
    • 1
    • 2
  • Pawan K. Singal
    • 1
    • 2
  1. 1.Division of Cardiovascular SciencesSt. Boniface General Hospital Research CentreWinnipegCanada
  2. 2.Department of Physiology Faculty of MedicineUniversity of ManitobaWinnipegCanada

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