Molecular and Cellular Biochemistry

, Volume 147, Issue 1–2, pp 77–81 | Cite as

Oxidative stress and heart failure

  • Neelam Singh
  • Arvinder K. Dhalla
  • Charita Seneviratne
  • Pawan K. Singal
Part II: Myocytic Adaptation and Myocardial Injury


Various abnormalities have been implicated in the transition of hypertrophy to heart failure but the exact mechanism is still unknown. Thus heart failure subsequent to hypertrophy remains a major clinical problem. Recently, oxidative stress has been suggested to play a critical role in the pathogenesis of heart failure. Here we describe antioxidant changes as well as their significance during hypertrophy and heart failure stages. Heart hypertrophy in rats and guinea pigs, in response to pressure over-load, is associated with an increase in ‘antioxidant reserve’ and a decrease in oxidative stress. Hypertrophied rat hearts show increased tolerance for different oxidative stress conditions such as those imposed by free radicals, hypoxia-reoxygenation and ischemia-reperfusion. On the other hand, heart failure under acute as well as chronic conditions is associated with reduced antioxidant reserve and increased oxidative stress. The latter may have a causal role as suggested by the protection seen with antioxidant treatment in acute as well as in chronic heart failure. It is becoming increasingly apparent that, anytime the available antioxidant reserve in the cell becomes inadequate, myocardial dysfunction is imminent.

Key words

antioxidants redox state lipid peroxidation 


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Copyright information

© Kluwer Academic Publishers 1995

Authors and Affiliations

  • Neelam Singh
    • 1
    • 2
  • Arvinder K. Dhalla
    • 1
    • 2
  • Charita Seneviratne
    • 1
    • 2
  • Pawan K. Singal
    • 1
    • 2
  1. 1.Division of Cardiovascular SciencesSt. Boniface General Hospital Research CentreWinnipegCanada
  2. 2.Department of Physiology Faculty of MedicineUniversity of ManitobaWinnipegCanada

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