European Journal of Nuclear Medicine

, Volume 22, Issue 4, pp 351–355 | Cite as

External reference markers for the correction of head rotation in brain single-photon emission tomography

  • William D. Leslie
  • Andrew Borys
  • Donna McDonald
  • Jacqueline O. Dupont
  • Anne E. Peterdy
Original article


Accurate reorientation of brain single-photon emission tomography (SPET) is required for quantitative procedures and for correlation with other imaging modalities. Traditionally, brain SPET has utilized reoriented slices parallel to the orbitomeatal line (OML). Reorientation using internal landmarks would be more convenient but has not been systematically compared with the use of external landmarks. We compared the interobserver reproducibility for defining the sagittal and coronal angular deviations using internal landmarks, a visual method based upon external reference markers, and an automated method based upon external reference markers. Internal landmarks were inaccurate for defining the OML whether this was based upon the frontal-occipital or frontal-cerebellar plane. External reference markers resulted in significantly lower interobserver differences for both sagittal and coronal reorientation. An operator-independent implementation proved to be feasible and provided an objective measure of marker coplanarity. In summary, external reference markers should be used when reproducible reorientation and ROI placement are required.

Key words

Single-photon emission tomography Reorientation Neuroimaging 


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  1. 1.
    Jolles PR, Chapman PR, Alavi A. PET, CT, and MRI in the evaluation of neuropsychiatric disorders: current applications.J Nucl Med 1989; 30:1589–1606.PubMedGoogle Scholar
  2. 2.
    Costa DC, Ell PJ.Brain blood flow in neurology and psychiatry. Edinburgh London Melbourne New York: Churchill Livingstone, 1991.Google Scholar
  3. 3.
    Hooper HR, McEwan AJ, Lentle BC, Kotchon TL, Hooper PM. Interactive three-dimensional region of interest analysis of HMPAO SPECT brain studies.J Nucl Med 1990: 31:2046–2051.PubMedGoogle Scholar
  4. 4.
    Baxter LR, Phelps ME, Mazziotta JC, Guze BH, Schwartz JM, Selin CE. Local cerebral glucose metabolic rates in obsessive-compulsive disorder.Arch Gen Psychiatry 1987; 44:211–218.PubMedGoogle Scholar
  5. 5.
    Waldemar G, Hasselbach SG, Anderson AR, Delecluse F, Petersen P, Johnsen A, Paulson OB.99mTc-d,1-HMPAO and SPECT of the brain in normal aging.J Cereb Blood Flow Metab 1991: 2:508–521.Google Scholar
  6. 6.
    Ichise M, Salit IE, Abbey SE, Chung DG, Gray B, Kirsh JC, Freedman M. Assessment of regional cerebral perfusion by99Tcm-HMPAO SPECT in chronic fatigue syndrome.Nucl Med Commun 1992; 13: 767–772.PubMedGoogle Scholar
  7. 7.
    Ebmeier KP, Murray CL, Dougall NJ, O'Carroll RE, Goddwin GM. Unilateral voluntary hand movement and regional cerebral uptake of technetium-99m-exametazime in human control subjects.J Nucl Med 1992; 33: 1637–1641.PubMedGoogle Scholar
  8. 8.
    Phillips RL, London ED, Links JM, Cascella NG. Program for PET alignment effects on calculated differences in cerebral metabolic rates for glucose.J Nucl Med 1990; 31: 2052–2057.PubMedGoogle Scholar
  9. 9.
    Seitz RJ, Bohm C, Greitz T. Accuracy and precision of the computerized brain atlas programme for localization and quantification in positron emission tomography.J Cereb Blood Flow Metab 1990; 10: 443–457.PubMedGoogle Scholar
  10. 10.
    Toyama H, Ichise M, Ballinger JR, Fornazzari L, Kirsh JC. Dopamine D2 receptor SPECT imaging: basic in vivo characteristics and clinical applications of123I-IBZM in humans.Ann Nucl Med 1993; 7: 29–38.PubMedGoogle Scholar
  11. 11.
    Steinmetz H, Huang Y, Seitz RJ, Knorr U, Schlaug G, Herzog H, Hacklander T, Freund HJ. Individual integration of positron emission tomography and high-resolution magnetic resonance imaging.J Cereb Blood Flow Metab 1992; 12: 919–926.PubMedGoogle Scholar
  12. 12.
    Woods RP, Cherry SR, Mazziotta JC. Rapid automated algorithm for aligning and reslicing PET images.J Comput Assist Tomogr 1992; 16: 620–633.PubMedGoogle Scholar
  13. 13.
    Zhang J, Levesque MF, Wilson CL, Harper RM, Engel J, Lufkin R, Behnke EJ. Multimodality imaging of brain structures for stereotactic surgery.Radiology 1991; 175: 435–441.Google Scholar
  14. 14.
    Bettinardi V, Scardaoni R, Gilardi MC, Rizzo G, Perani D, Paulesu E, Striano G, Triulzi F, Fazio F. Head holder for PET, CT and MR studies.J Comput Assist Tomogr 1991; 15: 886–892.PubMedGoogle Scholar
  15. 15.
    Evans AC, Marrett S, Torrescorzo J, Ku S, Collins L. MRI-PET correlation in three dimensions using a volume-of-interest (VOI) atlas.J Cereb Blood Flow Metab 1991; 11 Suppl 1: A69-A78.PubMedGoogle Scholar
  16. 16.
    Junck L, Moen GD, Brown MB, Kuhl DE. Correlation methods for the centering, rotation, and alignment of functional brain images.J Nucl Med 1990; 31: 1220–1276.PubMedGoogle Scholar
  17. 17.
    Minoshima S, Berger KL, Lee KS, Mintun MA. An automated method for rotational correction and centering of three-dimensional functional brain images.J Nucl Med 1992; 33: 1579–1585.PubMedGoogle Scholar
  18. 18.
    Johnson KA, Holman BL, Mueller SP, Rosen TJ, English R, Nagel IS, Growden JH. Single photon emission computed tomography in Alzheimer's disease.Arch Neurol 1988; 45: 392–396.PubMedGoogle Scholar
  19. 19.
    Podreka I, Baumgartner C, Suess E, Muller C, Brucke T, Lang W, Holzner F, Steiner M, Deecke L. Quantification of regional cerebral blood flow with IMP-SPECT.Stroke 1989; 20: 183–191.PubMedGoogle Scholar
  20. 20.
    Hellman RS, Tikofsky RS. An overview of the contribution of regional cerebral blood flow studies in cerebrovascular disease: is there a role for single photon emission computed tomography.Semin Nucl Med 1990; 20: 303–324.PubMedGoogle Scholar
  21. 21.
    Johnson KA, Sperling RA, Holman BL, Nagel JS, Growdon JH. Cerebral perfusion in progressive supranuclear palsy.J Nucl Med 1992; 33: 704–709.PubMedGoogle Scholar
  22. 22.
    Dobbeleir A, Dierckx R. Quantification of technetium-99m hexamethylpropylene amine oxime brain uptake in routine clinical practice using calibrated point sources as an external standard: phantom and human studies.Eur J Nucl Med 1993; 20: 684–689.PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • William D. Leslie
    • 1
  • Andrew Borys
    • 1
  • Donna McDonald
    • 1
  • Jacqueline O. Dupont
    • 1
  • Anne E. Peterdy
    • 1
  1. 1.Section of Nuclear MedicineUniversity of ManitobaWinnipegCanada

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