Surgery Today

, Volume 27, Issue 4, pp 293–297 | Cite as

Soybean agglutinin binding as a useful prognostic indicator in stomach cancer

  • Shinya Terashima
  • Yoshinao Takano
  • Takeo Ohori
  • Tomoyuki Kanno
  • Takuya Kimura
  • Ryoichi Motoki
  • Takanori Kawaguchi
Original Articles


Soybean agglutinin (SBA)-binding carbohydrate expression was studied immunohistochemically in 353 primary gastric carcinomas. The overall rate of positive SBA staining was 23% (81/353), and positive SBA staining was significantly correlated with tumor size, macroscopic tumor type, depth of invasion, lymph node metastasis, and venous invasion (P < 0.05). Moreover, patients with tumors that were immunoreactive for SBA demonstrated significantly higher survival (P < 0.01). From these findings we conclude that careful follow-up and intense postoperative therapy are required for patients with gastric cancers that lack immunoreactivity for SBA.

Key Words

lectin histochemistry soybean agglutinin stomach cancer 


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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • Shinya Terashima
    • 1
  • Yoshinao Takano
    • 1
  • Takeo Ohori
    • 1
  • Tomoyuki Kanno
    • 1
  • Takuya Kimura
    • 1
  • Ryoichi Motoki
    • 1
  • Takanori Kawaguchi
    • 2
  1. 1.First Department of SurgeryFukushima Medical SchoolFukushimaJapan
  2. 2.Second Department of PathologyFukushima Medical SchoolFukushimaJapan

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