Effect of aeration rate and influence of pCO2 in large-scale cultures ofCatharanthus roseus cells
Catharanthus roseus cells were grown at various aeration rates using normal or CO2-enriched air. Kinetic data showed a detrimental effect of the increase of the gassing rate on the growth characteristics due to CO2 stripping. When the CO2 partial pressure in the culture was maintained at a constant level of 20 mbar, better growth and enhanced conversion yields were obtained.
KeywordsPartial Pressure Detrimental Effect Aeration Kinetic Data Growth Characteristic
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