Electron microscope studies on the development of the external zone of the mouse median eminence
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The development of the external zone of the median eminence of the mouse was studied in the electron microscope. The examination follows the development of the embryo from the 15th day of the gestation period and the juvenile growth until 24 days of age.
Single terminals of the tubero-infundibular neurons of the external zone were found to extend to the outer basement membrane of the perivascular space of the portal primary capillary plexus in the 16 day-old embryo. In the 18 day-old embryo a narrow external zone has developed. Organization of the external zone into the adult pattern is accomplished at the age of three to four weeks. Small agranular as well as large granular vesicles are present in the tubero-infundibular nerve terminals even in the 16 day-old embryo.
Changes in the organization of the nerve endings along the outer perivascular basement membrane in relation to the ependymal vascular feet were considered.
Key-WordsMedian eminence Mouse Growth and development Ultrastructure
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- Corrodi, H., Jonsson, G.: The formaldehyde fluorescence method for the histological demonstration of biogenic amines. A review on the methodology. J. Histochem. Cytochem.15, 65–78 (1967).Google Scholar
- Enemar, A.: The structure and development of the hypophysial portal system in the laboratory mouse, with particular regard to the primary plexus. Ark. Zool., II Ser.13, 203–252 (1961a).Google Scholar
- - Notes on the histogenesis of the hypophysis of the laboratory mouse, with special reference to its relation to the development of the hypophysial portal system. Kungl. Fysiogr. Sällsk. Handl., N. F.71, Nr.19 (1961b).Google Scholar
- Falck, B.: Cellular localization of monoamines. Progr. Brain Res.8, 28–44 (1964).Google Scholar
- —, Hillarp, N.- Å., Thieme, G., Torp, A.: Fluorescence of catecholamines and related compounds condensed with formaldehyde. J. Histochem. Cytochem.10, 348–354 (1962).Google Scholar
- — —: Catecholamines in the hypothalamus and the pituitary gland. In: Frontiers in neuroendocrinology, p. 47–96, ed. by W. F. Ganong and L. Martini. New York-London-Toronto: Oxford University Press 1969.Google Scholar
- — —: Participation of central monoamine neurons in the regulation of anterior pituitary function with special regard to the neuroendocrine role of tubero-infundibular dopamine neurons. In: Aspects of neuroendocrinology, p. 192–205, eds. W. Bargmann, B. Scharrer. Berlin-Heidelberg-New York: Springer 1970.Google Scholar
- Ganong, W. F., Lorentzén, L.: Brain neurohumors and endocrine function. In: Neuroendocrinology, vol.2, p. 583–640, ed. by L. Martini and W. F. Ganong. New York-London: Academic Press 1967.Google Scholar
- Hökfelt, T.: Electron microscopic studies on peripheral and central monoamine neurons. In: Aspects of neuroendocrinology, p. 79–95, eds. W. Bargmann, B. Scharrer. Berlin-Heidelberg-New York: Springer 1970.Google Scholar
- Kobayashi, H., Oota, Y., Uemura, H., Hirano, T.: Electron microscopic and pharmacologic studies on the rat median eminence. Z. Zellforsch.71, 387–404 (1966).Google Scholar
- Kobayashi, T., Kobayashi, T., Yamamoto, K., Kaibara, M., Ajika, K.: Electron microscopic observation on the hypothalamo-hypophyseal system in rats. IV. Ultrafine structure of the developing median eminence. Endocr. jap.15, 337–363 (1968).Google Scholar
- — — — — —: Electron microscopic observations of axonal inclusions in rat median eminence. Endocr. jap., Suppl.1, 11–27 (1969).Google Scholar
- Matsui, T.: Fine structure of the median eminence of the rat. J. Fac. Sci. Univ. Tokyo4, 71–96 (1966).Google Scholar
- —: Effect of reserpine on the distribution of granulated vesicles in the mouse median eminence. Neuroendocrinology2, 99–106 (1967).Google Scholar
- Mazzuca, M.: Structure fine de l'éminence médiane du cobaye. J. Microscop.4, 225–238 (1965).Google Scholar
- Oota, Y.: Fine structure of the median eminence and pars nervosa of the mouse. J. Fac. Sci. Univ. Tokyo10, 155–168 (1963).Google Scholar
- Richardson, K. C.: Electron microscopic identification of autonomic nerve endings. Nature (Lond.)210, 756 (1966).Google Scholar
- —, Arstila, A. U.: Ultrastructure of the neurovascular link between the hypothalamus and the anterior pituitary gland in the median eminence of the rat. Neuroendocrinology1, 214–227 (1966a).Google Scholar
- — —: Electron microscopic evidence on the significance of the granular and vesicular inclusions of the neurosecretory nerve endings in the median eminence of the rat. I. Ultrastructural alterations after reserpine injection. Med. Pharmacol. exp.15, 357–369 (1966b).Google Scholar
- Sano, Y., Odake, G., Takemoto, S.: Fluorescence microscopic and electron microscopic observations on the tuberohypophyseal tract. Neuroendocrinology2, 30–42 (1967).Google Scholar
- Szentágothai, J., Flerkó, B., Mess, B., Halász, B.: Hypothalamic control of the anterior pituitary. Budapest: Akadémiai Kiadó 1962.Google Scholar