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The activity of nifluridide on reduviids and rodent and human trypanosomes

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Abstract

The ability of influridide to kill reduviids was assayed in mice fed 7 ppm in diet and on cattle injected subcutaneously at 5 mg/kg body weight. Nifluridide was systemically active againstTriatoma infestans on mice andRhodnius prolixus on cattle. No effects onTrypanosoma (Schizotrypanum) cruzi could be detected in the intestinal contents ofTriatoma infestans killed by the compound. In vitro and in vivo studies were conducted to determine the effects of nifluridide on trypanosomes growing in medium and in experimentally infected mice. Culture forms ofTrypanosoma cruzi grown at 27° C that are morphologically similar to epimastigotes found in infected bugs were affected by 2.5 to 10 ppm in the medium. Mice fed nifluridide in the diet simultaneous with infection ofTrypanosoma cruzi orTrypanosoma (Herpetosoma) musculi exhibited parasitemias and tissue infections similar to nontreated infected mice. At the concentration tested, bloodstream trypomastigotes and culture epimastigotes ofTrypanosoma musculi were unaffected by nifluridide. Only the culture epimastigotes ofTrypanosoma cruzi were affected by the drug but not the bloodstream and tissue forms.

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References

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Correspondence to R. J. Boisvenue.

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Dusanic, D.G., Boisvenue, R.J. The activity of nifluridide on reduviids and rodent and human trypanosomes. Z. Parasitenkd. 68, 155–160 (1982). https://doi.org/10.1007/BF00935056

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Keywords

  • Body Weight
  • Tissue Infection
  • Infected Mouse
  • Tissue Form
  • Intestinal Content