Tumor necrosis factor and pregnancy - a contribution to the immunology of reproduction
- Cite this article as:
- Voigt, H.J. & Steib, L. Arch Gynecol Obstet (1989) 246: 223. doi:10.1007/BF00934522
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Serum levels of the cytokine TNF (tumor necrosis factor) were determined in pregnant women during the first trimester and compared with levels in a control group of non-pregnant healthy women. A new immunoradiometric assay (IRMA) was used. In pregnant women we found a very low mean value of 2.5 pg/ml. The value was significantly higher 16.2 pg/ml in the non-pregnant group. This finding suggests supression of macrophage activity which could favour the fetal allograft.