Archives of Gynecology and Obstetrics

, Volume 246, Issue 4, pp 223–226

Tumor necrosis factor and pregnancy - a contribution to the immunology of reproduction

  • H. -J. Voigt
  • L. Steib

DOI: 10.1007/BF00934522

Cite this article as:
Voigt, H.J. & Steib, L. Arch Gynecol Obstet (1989) 246: 223. doi:10.1007/BF00934522


Serum levels of the cytokine TNF (tumor necrosis factor) were determined in pregnant women during the first trimester and compared with levels in a control group of non-pregnant healthy women. A new immunoradiometric assay (IRMA) was used. In pregnant women we found a very low mean value of 2.5 pg/ml. The value was significantly higher 16.2 pg/ml in the non-pregnant group. This finding suggests supression of macrophage activity which could favour the fetal allograft.

Key words

Tumor necrosis factor Immunology Early pregnancy 

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • H. -J. Voigt
    • 1
  • L. Steib
    • 1
  1. 1.Clinic for Gynecology and ObstetricsUniversity of ErlangenFRG
  2. 2.Abteilung für Geburtshilfe und Praenatale DiagnostikKlinik für Frauenheilkunde der Universität Erlangen-NürnbergErlangenFRG

Personalised recommendations