Parasitology Research

, Volume 79, Issue 3, pp 186–190

Eimeria sp. from the rabbit (Oryctolagus cuniculus): Pathogenicity and immunogenicity ofEimeria intestinalis

  • P. Coudert
  • D. Licois
  • F. Provôt
  • F. Drouet-Viard
Original Investigations


The pathogenicity and immunogenicity ofEimeria intestinalis was evaluated in SPF rabbits. The antimals were given immunizing doses of 6, 6×102, 6×103, and 6×104 sporulated oocysts and were challenged with 3×103 oocysts. The criteria analysed were the daily weight gain and the occyst output. This study showed thatE. intestinalis had strong immunogenicity, as the inoculation of 6 oocysts was sufficient to minimize the clinical expression of the disease following the challenge and to reduce the oocyst output by about 60%. The immunity towards the excretion of oocysts and the illness was absolute in animals inoculated with 600 or more oocysts. Moreover, this protection seemed to be efficient at least 8 weeks after the challenge. The present results also confirm the pathogenicity ofE. intestinalis, although the occurrence of diarrhoea may be irregular, and emphasize the fact that the capacity of thisEimeria for multiplication is not a criterion for clinical diagnosis of the disease.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Beyer T (1963) Immunity in experimental coccidiosis of the rabbit caused by heavy infective doses ofEimeria intestinalis. In: Ludvik J, et al. (eds) Progress in protozoology. Czech Academy of Sciences, Prague, p 448Google Scholar
  2. Coudert P (1976) Les coccidioses intestinales du lapin: comparaison du pouvoir pathogène d'Eimeria intestinalis avec trois autresEimeria. C R Séances Acad Sci [D] 282:2219–2222Google Scholar
  3. Coudert P (1977) Isolement et description d'une nouvelle espèce d'Eimeria chez le lapin (Oryctolagus cuniculus): Eimeria pellerdyi, (Sporozoa, Coccidia). C R Acad Sci (Paris) [D] 285:885–887Google Scholar
  4. Coudert P, Provôt F (1988) Lasalocid tolerance for the rabbit and activity againstE. flavescens andE. intestinalis. Proceedings of the 4th Congress of the World Rabbit Science Association 3:418–428Google Scholar
  5. Coudert P, Vaissaire J, Licois D (1977) Etude de l'évolution de quelques paramètres sanguins chez les lapereaux atteints de cocidiose intestinale. Recl Med Vet 154:437–440Google Scholar
  6. Coudert P, Licois D, Streun A (1979) Characterization ofEimeria species. I. Isolation and study of pathogenicity of a pure strain ofEimeria perforans (Leuckart 1879; Sluiter and Swellengrebel 1912). Z Parazitenkd 59:227–234Google Scholar
  7. Coudert P, Licois D, Besnard J (1988a) Establishment of a SPF breeding colony without hysterectomy and handrearing procedures. Proceedings of the 4th Congress of the World Rabbit Science Association 3:53–59Google Scholar
  8. Coudert P, Licois D, Provôt F (1988b) Differential diagnosis ofEimeria species from the rabbit. Proceedings of the 4th Congress of the World Rabbit Science Association 3:480Google Scholar
  9. Cringoli G, Quesada A, Coppola C (1986) Diffusione dei coccidi negli allevamenti cunicoli campani. Coniglicoltura 12:57–61Google Scholar
  10. Lebas F, Coudert P, Rouvier R, Rochambeau H de (1986) The rabbit: husbandry, health and production. (Animal production and health, vol 20) FAO, RomeGoogle Scholar
  11. Licois D, Coudert P,(1980) Attempt to suppress immunity in rabbits immunized againstEimeria intestinalis. Ann Rech Vet 11:273–278PubMedGoogle Scholar
  12. Licois D, Coudert P, Mongin P (1978a) Changes in hydromineral metabolism in diarrhoeic rabbits. 1. Study of the changes in water metabolism. Ann Rech Vet 9:1–10PubMedGoogle Scholar
  13. Licois D, Coudert P, Mongin P (1978b) Changes in hydromineral metabolism in diarrhoeic rabbits. 2. Study of the modifications of electrolyte metabolism. Ann Rech Vet 9:453–464PubMedGoogle Scholar
  14. Licois D, Coudert P, Boivin M, Viard F, Provot F (1988) Selection and characterization of a precocious line ofEimeria intestinalis an intestinal rabbit coccidium. Parasitol Res 76:192–198Google Scholar
  15. Licois D, Coudert P, Bahagia S, Rossi GL (1992) Endogenous development ofE. intestinalis in rabbits (Oryctolagus cuniculus). J Parasitol 78 (in press)Google Scholar
  16. Norton CC, Catchpole J, Joyner LP (1979) Redescription ofEimeria irresidua Kessel and Jankiewicz, 1931 andE. flavescens Marotel and Guilhon, 1941 from the domestic rabbit. Parasitology 79:231–248PubMedGoogle Scholar
  17. Peeters JE (1983) Rabbit coccidiosis and prevention. Cuni Sci 1:(2) [whole issue]Google Scholar
  18. Peeters JE, Geeroms R, Varewyck H, Bouquet Y, Lampo P, Halen P (1983) Immunity and effect of clopidol/methylbenzoquate and robenidine before and after weaning on rabbit coccidiosis in the field. Res Vet Sci 35:211–216PubMedGoogle Scholar
  19. Peeters JE, Charlier G, Antoine O, Mammerickx M (1984) Clinical and pathological changes afterEimeria intestinalis infection in rabbits. Zentralbl Vet Med 31:9–24Google Scholar
  20. Peeters JE, Geeroms R, Halen P (1988) Evolution of coccidial infection in commercial and domestic rabbits between 1982 and 1986. Vet Parasitol 29:327–331PubMedGoogle Scholar
  21. Rose ME (1959) A study of the life cycle ofEimeria stiedai (Lindemann, 1865) and the immunological response of the host. PhD thesis, University of CambridgeGoogle Scholar
  22. Salse A, Raynaud P (1985) Etude sur la flore caecale du lapin. Essai préliminaire d'implantation précoce de la flore adulte chez le lapereau. Ann Rech Vet 16:357–362PubMedGoogle Scholar
  23. Zanger C (1987) Untersuchungen über die Verbreitung der Parasiten des Hauskaninchens (Oryctolagus cuniculus F. domestica). Thesis, Tierärztliche Fakultät, Ludwig-Maximilians-Universität, MunichGoogle Scholar
  24. Zundel E, Renault L, Coudert P (1980) Coccidioses intestinales du lapin, sondage épidémiologique. Second World Rabbit Congress 15–18 Avril, Barcelona t II:308–314Google Scholar

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • P. Coudert
    • 1
  • D. Licois
    • 1
  • F. Provôt
    • 1
  • F. Drouet-Viard
    • 1
  1. 1.Laboratoire de Pathologie du Lapin, Station de Pathologie Aviaire et de ParasitologieI.N.R.A.MonnaieFrance

Personalised recommendations