Parasitology Research

, Volume 79, Issue 5, pp 435–438 | Cite as

Identification of truncated forms of lipophosphoglycan in mutant cloned lines ofLeishmania major that are deficient in mature lipophosphoglycan

  • Martin J. Elhay
  • Malcolm J. McConville
  • Joan M. Curtis
  • Antony Bacic
  • Emanuela Handman
Short Communications


Truncated Form 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Carver MA, Turco SJ (1991) Cell-free biosynthesis of lipophosphoglycan fromLeishmania donovani. Characterization of microsomal galactosyltransferase and mannosyltransferase activitics. J Biol Chem 266:10974–10981PubMedGoogle Scholar
  2. 2.
    Chan J, Fujiwara T, Brennan P, McNeil M, Turco SJ, Sibille JC, Snapper M, Aisen P, Bloom BR (1989) Microbial glycolipids: possible virulence factors that scavenge oxygen radicals. Proc Natl Acad Sci USA 86:2453–2457PubMedGoogle Scholar
  3. 3.
    Elhay MJ, Kellerher M, Bacic A, McConville MJ, Tolson DL, Pearson TW, Handman E (1990) Lipophosphoglycan expression and virulence in ricin-resistant variants ofLeishmania major. Mol Biochem Parasitol 40:255–267PubMedGoogle Scholar
  4. 4.
    El-On J, Bradley DJ, Freeman JC (1980)Leishmania donovani: action of excreted factor on hydrolytic enzyme activity of macrophages from mice with genetically different resistance to infection. Exp Parasitol 49:167–174PubMedGoogle Scholar
  5. 5.
    Handman E, Goding JW (1985) TheLeishmania receptor for macrophages is a lipid containing glycoconjugate. EMBO J 4:329–336PubMedGoogle Scholar
  6. 6.
    Handman E, Schnur L, Spithill TW, Mitchell GF (1986) Passive transfer ofLeishmania lipopolysaccharide confers parasite survival in macrophages. J Immunol 137:3608–3613PubMedGoogle Scholar
  7. 7.
    Kelleher M, Bacic A, Handman E (1992) Identification of a macrophage-binding determinant on lipophosphoglycan fromLeishmania major promastigotes. Proc Natl Acad Sci USA 89:6–10PubMedGoogle Scholar
  8. 8.
    McConville MJ, Bacic A (1989) A family of glycoinositol phospholipids fromLeishmania major. Isolation, characterization, and antigenicity. J Biol Chem 264:757–766PubMedGoogle Scholar
  9. 9.
    McConville MJ, Bacic A (1990) The glycoinositolphospholipid profiles of twoLeishmania major strains that differ in lipophosphoglycan expression. Mol Biochem Parasitol 38:57–68PubMedGoogle Scholar
  10. 10.
    McConville MJ, Bacic A, Mitchell GF, Handman E (1987) Lipophosphoglycan ofLeishmania major that vaccinates against cutaneous leishmaniasis contains an alkylglycerophosphoinositol lipid anchor. Proc Natl Acad Sci USA 84:8941–8945PubMedGoogle Scholar
  11. 11.
    McConville MJ, Thomas-Oates JE, Ferguson MAJ, Homans SW (1990) Structure of the lipophosphoglycan fromLeishmania major. J Biol Chem 265:19611–19623PubMedGoogle Scholar
  12. 12.
    McConville MJ, Homans SW, Thomas-Oates JE, Dell A, Bacic A (1990) Structures of the glycoinositolphospholipids fromLeishmania major. A family of novel galactofuranose-containing glycolipids. J Biol Chem 265:7385–7394PubMedGoogle Scholar
  13. 13.
    McNeely TB, Turco SJ (1990) Requirement of lipophosphoglycan for intracellular survival ofLeishmania donovani within human monocytes. J Immunol 144:2745–2750PubMedGoogle Scholar
  14. 14.
    Silva RP da, Hall BF, Joiner KA, Sacks DL (1989) CR1, and C3b receptor, mediates binding of infectiveLeishmania major metacyclic promastigotes to human macrophages. J Immunol 143:617–622PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Martin J. Elhay
    • 1
  • Malcolm J. McConville
    • 2
  • Joan M. Curtis
    • 3
  • Antony Bacic
    • 4
  • Emanuela Handman
    • 3
  1. 1.Centre for Animal Biotechnology, Faculty of Veterinary ScienceUniversity of MelbourneParkvilleAustralia
  2. 2.Department of BiochemistryUniversity of DundeeDundeeUK
  3. 3.The Walter and Eliza Hall Institute of Medical ResearchParkvilleAustralia
  4. 4.Plant Cell Biology Research Centre, School of BotanyUniversity of MelbourneParkvilleAustralia

Personalised recommendations