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Glucantime susceptibility ofLeishmania promastigotes under variable growth conditions

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Abstract

Growth inhibition ofLeishmania promastigotes by glucantime was compared in three different media. Glucantime inhibited the growth ofLeishmania cultured in complex medium but did not affect parasite growth when added to cells cultured in defined or semidefined media. Supplementation of the complex medium with biopterin partially reversed the glucantime effect in sensitive strains, although the addition of folic acid or oleic acid did not alter the activity of glucantime. Differences in fatty acid composition were observed between strains showing different degrees of glucantime susceptibility.

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Correspondence to Elizabeth Spangler.

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Spangler, E., de Araujo Soares, A.M.R.M. & de Lourdes Petrillo-Peixoto, M. Glucantime susceptibility ofLeishmania promastigotes under variable growth conditions. Parasitol Res 81, 291–295 (1995). https://doi.org/10.1007/BF00931532

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Keywords

  • Acid Composition
  • Folic Acid
  • Growth Condition
  • Oleic Acid
  • Fatty Acid Composition