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Molecular and Cellular Biochemistry

, Volume 124, Issue 2, pp 107–114 | Cite as

Inhibition of monoamine oxidase-A of rat brain by pyrethroids — anin vitro kinetic study

  • Gazula Valeswara Rao
  • K. S. Jagannatha Rao
Article

Abstract

Anin vitro kinetic study on inhibition of the monoamine oxidase-A (MAO-A) of the rat brain by two pyrethroids, namely permethrin (PM) and cypermethrin (CPM), has shown that PM and CPM competitively inhibit MAO-A by altering both the Michaelis-Menten constant (Km) and the maximum velocity (Vmax). Inhibitor constant values (Ki) indicated that CPM was a more effective inhibitor of MAO-A than PM. Both PM and CPM caused maximum inhibition of MAO-A at neutral pH. CPM significantly elevated the activation energy values of MAO-A as compared to those of PM.

Key words

permethrin cypermethrin monoamine oxidase-A 

Abbreviations

MAO

Manoamine Oxidase

PM

Permethrin

CPM

Cypermethrin

TTV

Toxicity Test Value

IC50

Inhibitor Concentration that causes 50 percent inhibition

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Copyright information

© Kluwer Academic Publishers 1993

Authors and Affiliations

  • Gazula Valeswara Rao
    • 1
  • K. S. Jagannatha Rao
    • 1
  1. 1.Department of Nutrition and Food SafetyCentral Food Technological Research InstituteMysoreIndia

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