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Synthesis of N1-methyldesthiobiotin

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N1-Methyldesthiobiotin was synthesized by starting with the ethyl ester ofα-ketodehydrodesthiobiotin.

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Literature cited

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    M. C. Scrutton, D. B. Keech, and M. T. Utter, J. Biol. Chem.,240, 574 (1965).

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    S. I. Zav'yalov, M. P. Unanyan, G. V. Kondrat'eva, and V. V. Filippov, Izv. Akad. Nauk SSSR, Ser. Khim.,1967, 1792.

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    R. Dushinsky and L. A. Dolan, J. Am. Chem. Soc.,67, 2073 (1945).

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We express our gratitude to prof. V. V. Filippov for testing (III) for biotin activity.

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 6, pp. 1416–1418, June, 1973.

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Zav'yalov, S.I., Zheleznaya, L.L. & Pavlova, A.B. Synthesis of N1-methyldesthiobiotin. Russ Chem Bull 22, 1380–1382 (1973). https://doi.org/10.1007/BF00928643

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  • Ester
  • Ethyl
  • Ethyl Ester