Collagen immunotyping of the hepatic fibrosis in human alveolar echinococcosis
- First Online:
- 50 Downloads
An extremely dense fibrosis is responsible for the main complications of alveolar echinococcosis (AE), a severe parasitic disease due to the development in the liver of a larval form of the cestodeEchinococcus multilocularis. Immunotyping of collagens present in fibrous, granulomatous, and normal areas of the liver was performed in nine patients with AE. Immunofluorescent labelling of collagen types showed that dense fibrosis was entirely composed of thick bundles of type I and type III collagens, surrounding old parasitic vesicles with an autofluorescent laminated layer. In granulomatous areas, collagens were labelled as clusters consisting mainly of type III procollagen and collagen. Concentric bundles of type III collagen surrounded active parasitic vesicles. An enhancement of the normal labelling in portal spaces of the intact liver was present in all the patients. These results suggest that irreversible acellular keloid scar-like fibrosis observed in AE is the ultimate result of cytotoxic and fibrogenetic events related to the immune response of the host which are taking place initially in the granulomatous area surrounding the young parasite larvae.
Unable to display preview. Download preview PDF.
- Grimaud JA (1983) Immunology of hepatic fibrosis. Contr Microbiol Immunol 7:190–197Google Scholar
- Miguet JP, Allemand H, Vuitton D, Carbillet JP, Gillet M (1982) L'échinococcose alvéolaire hépatique. Encycl Med Chir (Paris); 7023 A20Google Scholar
- Phillips SM, Fox EG (1982) Immunopathology of parasitic disease. Clin Immunol Allergy 2:667–703Google Scholar
- Sakamoto T, Sugimura M (1970) Studies on echinococcosis XXI. Electron microscopical observations on general structure of larval tissue ofEchinococcus multilocularis. Jap J Vet Res 17:67–80Google Scholar
- Schmidt GD, Roberts LS (1977) Foundations of parasitology. Mosby, Saint LouisGoogle Scholar