Zeitschrift für Parasitenkunde

, Volume 63, Issue 2, pp 113–128

Light and electron microscopic studies on the effect of praziquantel onSchistosoma mansoni, Dicrocoelium dendriticum, andFasciola hepatica (trematoda) in vitro

  • B. Becker
  • H. Mehlhorn
  • P. Andrews
  • H. Thomas
  • J. Eckert
Original Investigations


The fine structure of the tegument of three trematode species,Schistosoma mansoni, Dicrocoelium dendriticum, andFasciola hepatica, was studied by means of light scanning (SEM) and transmission electron microscopy (TEM) after in vitro exposure to 0, 1,10, and 100 μg/ml of the anthelmintic praziquantel for 5, 15, 30, and 60 min. InS. mansoni andD. dendriticum the resulting vacuolization of the tegument was confined to numerous small areas scattered all over the surface of the parasites and this finally led to the disruption of the apical tegumental layer. No changes were found in the tegument ofF. hepatica after treatment with praziquantel.

Key words

Schistosoma mansoni Dicrocoelium dendriticum Fasciola hepatica Praziquantel Fine structure Tegument 





Basement layer


Circular musculature


Genital atrium


Gynaecophoric canal


Inclusion bodies


Interstitial material


Longitudinal musculature




Oral sucker






Surface pits








Ventral sucker


Scanning electron microscopy


Transmission electron microscopy


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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • B. Becker
    • 1
  • H. Mehlhorn
    • 1
  • P. Andrews
    • 2
  • H. Thomas
    • 2
  • J. Eckert
    • 3
  1. 1.Institut für Zoologie II der Universität DüsseldorfDüsseldorf 1Germany
  2. 2.Bayer Pharma-ForschungszentrumInstitut für ChemotherapieWuppertal 1Germany
  3. 3.Institut für Parasitologie der Universität ZürichZürichSwitzerland

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