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Carbonylation reaction

Communication 17. Synthesis of N-substituted amides of propionic acid from ethylene, carbon monoxide, and amines in the presence of mercury acetate

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Conclusions

  1. 1.

    The carbonylation of ethylene with CO in either an aliphatic or a cyclic secondary amine as the medium, in the presence of mercury acetate, at 150–250° and an initial pressure of 60–75 atm, leads to the formation of the corresponding propionic acid N-substituted amide in up to 50% yield and higher when based on amine taken for reaction.

  2. 2.

    Under analogous conditions, propionic acid anilide is formed from aniline, C2H4 and CO in up to 80% yield and higher when based on starting amine.

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Literature cited

  1. 1.

    B. K. Nefedov, N. S. Sergeeva, and Ya. T. Éidus, Izv. Akad. Nauk SSSR, Ser. Khim., 807 (1973).

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    B. K. Nefedov, N. S. Sergeeva, and Ya. T. Éidus, Izv. Akad. Nauk SSSR, Ser. Khim., 1751, 1753 (1972).

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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 3, pp. 608–612, March, 1974.

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Nefedov, B.K., Sergeeva, N.S. & Éidus, Y.T. Carbonylation reaction. Russ Chem Bull 23, 573–576 (1974). https://doi.org/10.1007/BF00921147

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Keywords

  • Acetate
  • Ethylene
  • Mercury
  • Amide
  • Carbonylation