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Immunohistology of eye muscle in idiopathic orbital inflammatory disease (pseudotumor), Grave's ophthalmopathy and healthy controls

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Inflammatory orbital disease can be triggered by a variety of causes. Two such diseases are pseudotumor orbitae and Grave's ophthalmopathy, and both involve extraocular muscles during a quiet phase in these two diseases. Biopsies obtained from a previous pseudotumor orbitae showed complement deposits and increased expression of HLA class-I antigens in the intermuscular tissue. The biopsies from two out of our pseudotumor cases and two out of four Grave's ophthalmophathy cases contained increased numbers of intermuscular HLA class-II-expressing cells. In spite of clinical remission, the local condition in all four pseudotumor cases and in two out of four cases of Grave's ophthalmopathy still suggests active inflammatory disease.

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Correspondence to Robert J. W. de Keizer.

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Lenderink, T., Jager, M.J., Bruijn, J. et al. Immunohistology of eye muscle in idiopathic orbital inflammatory disease (pseudotumor), Grave's ophthalmopathy and healthy controls. Graefe's Arch Clin Exp Ophthalmol 231, 99–103 (1993). https://doi.org/10.1007/BF00920221

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  • Public Health
  • Inflammatory Disease
  • Local Condition
  • Clinical Remission
  • Extraocular Muscle