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Clinical course and pathologic features of conjunctival non-Hodgkin's lymphoma

A report of six cases
  • Hussein A. Khalil
  • Rob JW de Keizer
  • Philip M. Kluin
  • Hanneke C. Kluin-Nelemans
  • Didi de Wolff-Rouendaal
Clinical Investigations

Abstract

Six patients with conjunctival non-Hodgkin's lymphoma (NHL) were evaluated. In all six cases the conjunctiva was the primary site of clinical presentation; four cases involved low-grade malignancy and two, intermediate-grade malignancy, according to the International Working Formulation. The disease developed within a short period of time to stage IV The poor response to therapy revealed a worse prognosis than would be expected according to the histopathologic classification. Four of the six patients died of NHL, three of them within 15 months. Comparison of these 6 cases with a group of 15 patients with orbital NHL revealed a much better prognosis in the latter patients. In spite of the fact that 4 of the 15 orbital cases showed NHL of high-grade malignancy, only 2 of them died of the lymphoma. Therefore, conjunctival NHL requires a fast and adequate diagnostic and therapeutic approach.

Keywords

Public Health Lymphoma Therapeutic Approach Good Prognosis Pathologic Feature 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Hussein A. Khalil
    • 1
  • Rob JW de Keizer
    • 1
  • Philip M. Kluin
    • 3
  • Hanneke C. Kluin-Nelemans
    • 2
  • Didi de Wolff-Rouendaal
    • 1
  1. 1.Department of OphthalmologyUniversity HospitalLeidenThe Netherlands
  2. 2.Department of HematologyUniversity HospitalLeidenThe Netherlands
  3. 3.Department of PathologyLeiden UniversityLeidenThe Netherlands

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