Clinical course and pathologic features of conjunctival non-Hodgkin's lymphoma

A report of six cases
  • Hussein A. Khalil
  • Rob JW de Keizer
  • Philip M. Kluin
  • Hanneke C. Kluin-Nelemans
  • Didi de Wolff-Rouendaal
Clinical Investigations


Six patients with conjunctival non-Hodgkin's lymphoma (NHL) were evaluated. In all six cases the conjunctiva was the primary site of clinical presentation; four cases involved low-grade malignancy and two, intermediate-grade malignancy, according to the International Working Formulation. The disease developed within a short period of time to stage IV The poor response to therapy revealed a worse prognosis than would be expected according to the histopathologic classification. Four of the six patients died of NHL, three of them within 15 months. Comparison of these 6 cases with a group of 15 patients with orbital NHL revealed a much better prognosis in the latter patients. In spite of the fact that 4 of the 15 orbital cases showed NHL of high-grade malignancy, only 2 of them died of the lymphoma. Therefore, conjunctival NHL requires a fast and adequate diagnostic and therapeutic approach.


Public Health Lymphoma Therapeutic Approach Good Prognosis Pathologic Feature 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Hussein A. Khalil
    • 1
  • Rob JW de Keizer
    • 1
  • Philip M. Kluin
    • 3
  • Hanneke C. Kluin-Nelemans
    • 2
  • Didi de Wolff-Rouendaal
    • 1
  1. 1.Department of OphthalmologyUniversity HospitalLeidenThe Netherlands
  2. 2.Department of HematologyUniversity HospitalLeidenThe Netherlands
  3. 3.Department of PathologyLeiden UniversityLeidenThe Netherlands

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