Journal of Neurology

, Volume 241, Issue 8, pp 463–469

Intranasal sumatriptan for the acute treatment of migraine

  • R. Salonen
  • E. Ashford
  • C. Dahlöf
  • R. Dawson
  • N. E. Gilhus
  • V. Lüben
  • D. Noronha
  • J. M. Warter
Original Communication

DOI: 10.1007/BF00919706

Cite this article as:
Salonen, R., Ashford, E., Dahlöf, C. et al. J Neurol (1994) 241: 463. doi:10.1007/BF00919706

Abstract

Two double-blind, placebo-controlled, randomised, multicenter, multinational, parallel-group studies were carried out to identify the optimum dose of intranasal sumatriptan for the acute treatment of migraine. Study medication was taken as a single dose through one nostril in the first study, and as a divided dose through two nostrils in the second study. Totals of 245 and 210 patients with a history of migraine were recruited into the one-and two-nostril studies, respectively. In both studies, headache severity had significantly improved at 120 min after doses of 10–40 mg sumatriptan compared to placebo (P < 0.05) and the greatest efficacy rates were obtained with 20 mg sumatriptan. With 20 mg sumatriptan 78% and 74% of patients experienced headache relief in one- and two-nostril studies respectively. Sumatriptan was generally well tolerated, the most frequently reported event being taste disturbance. The results of the two studies are similar and indicate that administering sumatriptan as a divided dose via two nostrils confers no significant advantage over single-nostril administration.

Key words

Sumatriptan Migraine Intranasal administration Acute therapy 

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • R. Salonen
    • 1
  • E. Ashford
    • 2
  • C. Dahlöf
    • 3
  • R. Dawson
    • 2
  • N. E. Gilhus
    • 4
  • V. Lüben
    • 5
  • D. Noronha
    • 2
  • J. M. Warter
    • 6
  1. 1.Department of NeurologyUniversity of TurkuTurkuFinland
  2. 2.Glaxo Group Research LimitedGreenfordUK
  3. 3.Gothenburg Migraine ClinicGothenburgSweden
  4. 4.Department of NeurologyUniversity of BergenNorway
  5. 5.Funktionsbereich SchmerztherapieJustus-Liebig-UniversityGiessenGermany
  6. 6.Clinique NeurologiqueHopitaux Universitaires de StrasbourgFrance

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