Vasospasm appears to be a probable risk factor in the development of glaucoma. Transcranial Doppler (TCD) can detect vasospasm in cerebral vessels. It gives reproducible readings for ophthalmic artery blood velocity measurements. We used the TCD to measure peak flow velocity, mean flow velocity, and end-diastolic flow velocity in the ophthalmic artery and a laser Doppler flow meter to measure blood flow in the fingers of 17 patients with chronic open-angle glaucoma (COAG), 13 patients with normal tension glaucoma (NTG), and 8 nonglaucomatous subjects with normal eyes (normals). The opposite hand to that in which the measurements were made was challenged with warm (40°) and cold (4°) water. Five measurements of the ophthalmic artery velocity and finger flow were recorded: the first at baseline, the second during warming of the hand, the third after warming of the hand, the fourth when the hand was immersed in iced water, and the fifth after the hand was removed from the cold water. There was no detectable change in the ophthalmic artery blood velocities but significant decreases in the finger flow measurements when the opposite hand was immersed in cold water. These changes were present in all three diagnostic groups (P<0.001 for COAG;P<0.005 for NTG;P<0.05 for normals). The findings suggest a reflex vasospasm to cold in the finger circulation of most persons but no measurable changes in the ophthalmic artery.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Aaslid R, Huber P, Nornes H (1984) Evaluation of cerebrovascular spasm with transcranial Doppler ultrasound. J Neurosurg 60:37–41
Drance SM, Douglas GR, Wijsman K, Schulzer M, Britton RJ (1988) Response of blood flow to warm and cold in normal and low-tension glaucoma patients. Am J Ophthalmol 105:3539
Flammer J, Guthauser U, Mahler F (1987) In: Greve EL, Heisl A, Junk W (eds) Do ocular vasospasms help cause low tension glaucoma? Doc Ophthalmol Proc Set, pp 397–399
Gasser P (1989) Ocular vasospasm: a risk factor in the pathogenesis of low-tension glaucoma. Int Ophthalmology 13:281–290
Gasser P, Flammer J (1991) Blood-cell velocity in the nailfold capillaries of patients with normal-tension and high-tension glaucoma. Am J Ophthalmol 111:585–588
Gasser P, Flammer J (1990) Short- and long term effect of nifedipine on the visual field in patient with presumed vasospasm. J Int Med Res 18:334–339
Hupp SL, Kline LB, Corbett JJ (1988) Visual disturbance of migraine. Surv Ophthalmol 33:221–236
Kitazawa Y, Shirai H, Go FJ (1989) The effect of Ca2+-antagonist on visual field in low-tension glaucoma. Graefes Arch Clin Exp Ophthalmol 227:408–412
Phelps D, Corbett JJ (1985) Migraine and low-tension glaucoma. A case-control study. Invest Ophthalmol Vis Sci 26:1105–1108
Prunte C, Flammer J (1989) Choroidal angiography findings in patients with glaucoma-like visual field defects. In: Heijl A (eds) Perimetry update 1988/89. Kugler & Ghedini, Amsterdam, pp 325–327
Rojanapongpun P, Morrison BJ, Drance SM (1993) Ophthalmic artery flow velocity by transcranial Doppler ultrasound: reproducibility and potential application in ophthalmology. Br J Ophthal 77: 22–24
Schulzer M, Drance SM, Carter CJ, Brooks DE, Douglas GR, Lau W (1990) Biostatistical evidence for two distinct chronic open angle populations. Br J Ophthalmol 74:196–200
Sommer A (1989) Intraocular pressure and glaucoma. Am J Ophthalmol 107:186–188
Thie A, Spitzer K, Lachenmayer L, Kunze K (1988) Prolonged vasospasm in migraine detected by noninvasive transcranial Doppler ultrasound. Headache 28:183–186
About this article
Cite this article
Rojanapongpun, P., Drance, S.M. The response of blood flow velocity in the ophthalmic artery and blood flow of the finger to warm and cold stimuli in glaucomatous patients. Graefe's Arch Clin Exp Ophthalmol 231, 375–377 (1993). https://doi.org/10.1007/BF00919643
- Blood Flow Velocity
- Glaucomatous Patient
- Ophthalmic Artery
- Measure Blood Flow