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Inflammation

, Volume 16, Issue 6, pp 623–629 | Cite as

Mucosal protective activity of prostaglandin analogs in rodent colonic inflammation

  • D. J. Fretland
  • D. L. Widomski
  • C. P. Anglin
  • R. E. Walsh
  • S. Levin
  • A. F. Gasiecki
  • P. W. Collins
Original Articles

Abstract

The mucosal protective prostaglandin analogs misoprostol, enisoprost, and SC-46275 (the 17E-18-cyclopentenyl analog of enisoprost) were tested in mouse and rat colitis induced by the intrarectal instillation of dilute acetic acid. Colitis was assessed by histology and colonic levels of myeloperoxidase (a neutrophil marker enzyme). When given as enemas 30 min ahead of colitis induction, 15(R)-15-methyl-PGE2 (arbaprostil) and 15(S)-15-methyl-PGE1 were inactive; however, misoprostol, enisoprost, and SC-46275 protected against colonic inflammation with ED50 values of 24, 12 and 1.3μg/kg, respectively, in rats and 11, 5, and 1μg/kg, respectively, in mice. These compounds may have utility in the medical management of human inflammatory bowel disease.

Keywords

Acetic Acid Prostaglandin Inflammatory Bowel Disease Bowel Disease Medical Management 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • D. J. Fretland
    • 1
  • D. L. Widomski
    • 1
  • C. P. Anglin
    • 1
  • R. E. Walsh
    • 1
  • S. Levin
    • 2
  • A. F. Gasiecki
    • 3
  • P. W. Collins
    • 3
  1. 1.Department of ImmunoInflammatory Diseases ResearchSearle Research and Development
  2. 2.Department of PathologySearle Research and Development
  3. 3.Department of ChemistrySearle Research and Development

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