Journal of Clinical Immunology

, Volume 10, Issue 2, pp 81–89 | Cite as

Intravenous immunoglobulin (IVIG) for the therapy of autoimmune disorders

  • Stanley A. Schwartz
Special Article


The weight of evidence from numerous clinical studies supports the use of IVIG, particularly at higher doses, in the treatment of a wide range of autoimmune disorders. Extensive experience has documented the safety of IVIG therapy but its present relatively high cost necessitates firmly establishing its efficacy. There is an acute need to define those disease states where IVIG is indicated and effective. Large-scale, possibly multicentered, clinical trials employing rigorous controls will resolve these questions. Concurrent fundamental immunologic studies will elucidate the mechanisms underlying the clinical effects. We are experiencing an exciting new era of effective immunotherapies and intravenous gamma-globulin preparations have already secured an important place in the therapeutic armamentarium. While one must guard against unsubstantiated applications, critical exploration of new uses for this unique product is warranted.

Key words

Intravenous immunoglobulin autoimmunity immunomodulation 


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Copyright information

© Plenum Publishing Corporation 1990

Authors and Affiliations

  • Stanley A. Schwartz
    • 1
  1. 1.Departments of Pediatrics, Microbiology/Immunology, and EpidemiologyThe University of MichiganAnn Arbor

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