Conjunctival epithelial cells from patients with Sjögren's syndrome inappropriately express major histocompatibility complex molecules, La(SSB) antigen, and heat-shock proteins
- 35 Downloads
The La(SSB) antigen has been detected within the cytoplasm and on the membrane of conjunctival cells (CC) from patients with Sjögren's syndrome, whereas it was weakly expressed in the nucleus of normal cells. The diseased CC were shown to overproduce major histocompatibility complex (MHC) class I antigens and express MHC class II antigens. Anti-heat-shock protein monoclonal antibody bound to the cell membrane in patients but not in normal controls.
Key wordsSjögren's syndrome La(SSB) antigen epithelial cells
Unable to display preview. Download preview PDF.
- 8.Egbert PR, Lauber S, Maurice DM: A simple conjunctival biopsy. Am J Ophtalmol 84:789–801, 1977Google Scholar
- 13.Baudowin C, Fredj-Reygrobellet D, Lapalus P, Gastaud P: Immunopathological study on proliferative diabetic retinopathy. Am J Opthalmol 105:383–386, 1988Google Scholar
- 17.Norton PM, Isenberg DA, Latchman DS: Elevated levels of the 90kD heat-shock protein in a proportion of SLE patients with active disease J Autoimmun 2:187–195, 1989Google Scholar
- 19.Jarjour WN, Jeffries BD, Davis JS IV, Welch WJ, Mimura T, Winfield JB: Autoantibodies to human stress proteins. A survey of various rheumatic and other inflammatory diseases. Arth Rheum 34:1133–1137, 1991Google Scholar