Journal of Clinical Immunology

, Volume 12, Issue 4, pp 259–265 | Cite as

Conjunctival epithelial cells from patients with Sjögren's syndrome inappropriately express major histocompatibility complex molecules, La(SSB) antigen, and heat-shock proteins

  • Dimitri I. Yannopoulos
  • Stéphane Roncin
  • Armelle Lamour
  • Yvon L. Pennec
  • Haralampos M. Moutsopoulos
  • Pierre Youinou
Original Articles

Abstract

The La(SSB) antigen has been detected within the cytoplasm and on the membrane of conjunctival cells (CC) from patients with Sjögren's syndrome, whereas it was weakly expressed in the nucleus of normal cells. The diseased CC were shown to overproduce major histocompatibility complex (MHC) class I antigens and express MHC class II antigens. Anti-heat-shock protein monoclonal antibody bound to the cell membrane in patients but not in normal controls.

Key words

Sjögren's syndrome La(SSB) antigen epithelial cells 

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Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • Dimitri I. Yannopoulos
    • 1
  • Stéphane Roncin
    • 2
  • Armelle Lamour
    • 1
  • Yvon L. Pennec
    • 3
  • Haralampos M. Moutsopoulos
    • 1
  • Pierre Youinou
    • 1
  1. 1.Laboratory of ImmunologyBrest University Medical School HospitalBrest CedexFrance
  2. 2.Unit of OphthalmologyBrest University Medical SchoolBrestFrance
  3. 3.Department of Internal MedicineBrest University Medical SchoolBrestFrance

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