Chemiluminescence produced by normal cells was reduced in response to zymosan which was opsonized with serum from patients on prophylactic lithium therapy, compared to control serum from normal subjects (68±3.1 vs. 93±3.4 mV/5×105 cells). Preincubation of normal cells with serum from patients also resulted in reduced chemiluminescence activity when the cells were stimulated with autologous serum-coated zymosan (47±4.5 vs. 64±6.3 mV/5×105 cells). Spontaneous complement conversion was increased in the serum of patients on lithium therapy (46.3±3.8 vs. 25.3±2.5% conversion). These studies demonstrated that lithium, at safe therapeutic levels (0.4–0.9 mmol/liter), significantly altered complement conversion and had a marked affect on chemiluminescence activity by normal cells.
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O'Riordan, J.W., Kelleher, D., Williams, Y. et al. Effect of lithium therapy on inflammatory response. Inflammation 10, 49–57 (1986). https://doi.org/10.1007/BF00916040
- Public Health
- Internal Medicine
- Inflammatory Response
- Normal Cell