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Effect of feverfew on phagocytosis and killing ofCandida guilliermondii by neutrophils

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Abstract

The in vitro effect of the herbal remedy feverfew on neutrophil function was examined. It was shown that addition of feverfew extract inhibited phagocytosis ofCandida guilliermondii and its overall killing. However, intracellular killing was not affected, suggesting that the apparent defect in total killing merely reflected the failure of uptake. The implications for the in vivo effects of feverfew are discussed.

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References

  1. 1.

    Berry, M. I. 1984. Feverfew faces the future.Pharm. J. 232:611–614.

  2. 2.

    Heptinstall, S., A. White, L. Williamson, andJ. R. A. Mitchell. 1985. Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leucocytes.Lancet 1:1071–1074.

  3. 3.

    Hanington, E., R. J. Jones, J. A. L. Amess, andB. Wachowicz. 1981. Migraine: A platelet disorder.Lancet 2:720–723.

  4. 4.

    Howe, G. B., andJ. N. Fordham. 1981. Polymorphonuclear leucocytes. Origins, functions and roles in rheumatic disease.In Immunological Aspects of Rheumatology. W. Carson Dick, editor. MTP Press, Lancaster, 149–170.

  5. 5.

    Ferrante, A., andY. H. Thong. 1980. Optimal conditions for simultaneous purification of mononuclear and polymorphonuclear leucocytes from human blood by the Hypaque-Ficoll method.J. Immunol. Methods 36:109–117.

  6. 6.

    Bridges, C. G., G. L. Dasilva, M. Yamamura, andH. Valdimarsson. 1982. A radiometric assay for the combined measurement of phagocytosis and intracellular killing ofCandida albicans.Clin. Exp. Immunol. 42:226–233.

  7. 7.

    Johnson, E. S., N. P. Kadam, D. M. Hylands, P. J. Hylands. 1985. Efficacy of feverfew as prophylatic treatment of migraine.Br. Med. J. 291:569–573.

  8. 8.

    Hoffstein, S., I. M. Goldstein, andG. Weissmann. 1977. Role of microtubule assembly in lysosomal enzyme secretion from human polymorphonuclear leucocytes.J. Cell. Biol. 73:242–256.

  9. 9.

    Burchill, B. R., J. M. Oliver, C. B. Pearson, E. D. Leinbach, andD. Berlin. 1978. Microtubule dynamics and glutathione metabolism in phagocytosing human polymorphonuclear leukocytes.J. Cell Biol. 76:439–447.

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Williamson, L.M., Harvey, D.M., Sheppard, K.J. et al. Effect of feverfew on phagocytosis and killing ofCandida guilliermondii by neutrophils. Inflammation 12, 11–16 (1988). https://doi.org/10.1007/BF00915887

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Keywords

  • Public Health
  • Internal Medicine
  • Herbal Remedy
  • Neutrophil Function
  • Intracellular Killing