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Journal of Clinical Immunology

, Volume 3, Issue 4, pp 295–315 | Cite as

Regulation of the immune response by prostaglandins

  • James S. Goodwin
  • Jan Ceuppens
Special Article

Abstract

Of all the arachidonic acid metabolites, only prostaglandin E (PGE) has been shown to have a clear role in the regulation of cellular and humoral immune responses. In cellular immune responses such as T cell proliferation, lymphokine production, and cytotoxicity, PGE usually acts as a feedback inhibor of the response. This is also true of macrophage and natural killer cytotoxicity. In some instances PGE is responsible for cellular activation rather than inhibition. This is clearest in the control of humoral immunity, where PGE production is a necessary component in the generation of some type of T suppressor cells. Disturbances in immune function found in several human conditions and diseases have been linked to changes in PGE mediated immunoregulation. Either increased production of PGE or increased sensitivity to PGE results in depressed cellular immunity. Conversely drugs which inhibit PGE production act as stimulants of cellular immune functionin vitro andin vivo.

Key words

Prostaglandin E immune response suppressor cells cellular immunity humoral immunity immunoregulation non steroidal anti inflammatory agents 

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Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • James S. Goodwin
    • 1
  • Jan Ceuppens
    • 2
  1. 1.Department of MedicineUniversity of New Mexico School of MedicineAlbuquerque
  2. 2.Department of MedicineUniversity of LeuvenLeuvenBelgium

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